KMT2B

Gene Symbol KMT2B
Entrez Gene 9757
Alt Symbol CXXC10, HRX2, MLL1B, MLL2, MLL4, TRX2, WBP-7, WBP7
Species Human
Gene Type protein-coding
Description lysine (K)-specific methyltransferase 2B
Other Description WW domain binding protein 7|histone-lysine N-methyltransferase 2B|histone-lysine N-methyltransferase MLL4|mixed lineage leukemia gene homolog 2|myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) 4|myeloid/lymphoid or mixed-lineage leukemia protein 4|trithorax homologue 2
Swissprots Q9Y669 Q96IP3 Q96GP2 O95836 Q9UMN6 Q9UK25 O15022 Q9Y668
Accessions Q9UMN6 AB002302 BAA20763 AF104918 AAD17932 AF105279 AAD26113 AF105280 AAD26112 AF186605 AAD56420 AJ007041 CAB45385 BC007353 AAH07353 BC009337 AAH09337 BC026861 BM967067 XM_011527561 XP_011525863 XM_011527562 XP_011525864 XM_011527563 XP_011525865 XR_935878 NM_014727 NP_055542
Function Histone methyltransferase. Methylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in beta-globin locus transcription regulation by being recruited by NFE2. Plays an important role in controlling bulk H3K4me during oocyte growth and preimplantation development. Required during the transcriptionally active period of oocyte growth for the establishment and/or maintenance of bulk H3K4 trimethylation (H3K4me3), global transcriptional silencing that preceeds resumption of meiosis, oocyte survival and normal zygotic genome activation. {ECO:0000269|PubMed:17707229}.
Subcellular Location Nucleus {ECO:0000250}.
Tissue Specificity Widely expressed. Highest levels in testis. Also found in brain, bone marrow, heart, muscle, kidney, placenta, spleen, thymus, prostate, ovary, intestine, colon, peripheral blood lymphocytes and pancreas. Often amplified in pancreatic carcinomas.
Top Pathways Lysine degradation

MLL4 (N-14) - sc-68675 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MLL4 (N-14): sc-68675. Immunofluorescence staining of formalin-fixed HeLa cells showing nuclear localization. Kindly provided by Yang Xiang, Ph.D., Division of Newborn Medicine, Boston Childrens Hospital, Cell Biology Department, Harvard Medical School.

MLL4 (P-18) - sc-68676 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-KMT2B / MLL4 antibody - ab104444 from Abcam

Prices $407.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
ab104444, at 5 µg/ml, staining KMT2B / MLL4 in formalin-fixed, paraffin-embedded Human Brain, Cortex by Immunohistochemistry, using a biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Anti-KMT2B / MLL4 antibody [4C10] - ab56770 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C10
Western blot against tagged recombinant protein immunogen using ab56770 MLL4 antibody at 1ug/ml.

Anti-KMT2B / MLL4 Antibody (aa2403-2417) - LS-C3342 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KMT2B / MLL4 Antibody (C-Terminus) - LS-C155140 from LifeSpan Bioscience

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KMT2B / MLL4 Antibody (aa813-905) - LS-C309017 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-KMT2B / MLL4 Antibody (aa450-500) - LS-C288929 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KMT2B / MLL4 Antibody - LS-C342117 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KMT2B / MLL4 Antibody (aa84-133) - LS-C31703 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: HepG2 Cell Lysate

Anti-KMT2B / MLL4 Antibody (aa2375-2425) IHC-plus™ - LS-B11281 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-KMT2B / MLL4 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-KMT2B / MLL4 Antibody (aa2703-2715) IHC-plus™ - LS-B3595 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-MLL4 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3595 concentration 5 ug/ml.

KMT2B Antibody - NB600-254 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: KMT2B Antibody [NB600-254] - analysis of MLL4 in Jurkat cell lysate (30ug/lane) using anti-MLL4 antibody. The primary antibody was used at a dilution of 1:2000 in PBS, incubated for 3 hours at room temperature. Note: MLL4 is degraded very fast and this could be why this antibody and other MLL4 antibodies may give smaller size band. Image from verified customer review.

KMT2B Antibody - NB300-864 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemistry-Paraffin: MLL4 Antibody [NB300-864] - (5ug/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

KMT2B Antibody (1F6) - H00009757-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F6
Sandwich ELISA: KMT2B Antibody (1F6) [H00009757-M01] - Detection limit for recombinant GST tagged MLL4 is approximately 0.1ng/ml as a capture antibody.

KMT2B Antibody (4C10) - H00009757-M02 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C10
Sandwich ELISA: KMT2B Antibody (4C10) [H00009757-M02] - Detection limit for recombinant GST tagged MLL4 is approximately 0.03ng/ml as a capture antibody.

Anti-MLL4 antibody produced in rabbit - AV33704 from Sigma-Aldrich

Prices $267.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Cell Type: HepG2 (<B>Cat. No. AV33704</B>).<BR/><B>Lanes</B><BR/>1. Antibody dilution (concentration) 5 μg/mL in cell type HepG2

Anti-WBP7 antibody produced in rabbit - HPA006487 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-AD000671.3: <B>Cat. No. HPA006487</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human testis tissue showing strong nuclear positivity in spermatogonia.

Anti-KMT2D antibody produced in rabbit - SAB4301179 from Sigma-Aldrich

Prices $230.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MLL4 (C-terminal) antibody produced in goat - SAB2501638 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Monoclonal Anti-MLL4 antibody produced in mouse - SAB1404755 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F6
<B>Immunoblotting</B><BR/>Monoclonal Anti-MLL4: <B>Cat. No. SAB1404755</B>: Antibody concentration: 1 μg/mL. Specific band of ~36.2 kDa using immunogen protein lysate.

Monoclonal Anti-MLL4 antibody produced in mouse - WH0009757M2 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4C10
<B>Immunoblotting</B><BR/>Monoclonal Anti-MLL4, <B>Cat. No. WH0009757M2</B> used at the antibody concentration: 1 μg/mL. Specific band of ~36.23 kDa using immunogen protein lysate.

MLL4 antibody - N-terminal region (ARP33704_T100) - ARP33704_T100 from Aviva Systems Biology

Prices $229.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

MLL4-Antibody-C-Term - AF2297a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF2297a (5 µg/ml) staining of paraffin embedded Human Testis. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

MLL4-antibody-N-terminal-region - AI10100 from Abgent, a WuXi AppTec company

Prices $232.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
MLL4 antibody - N-terminal region (AI10100) in Human HepG2 cells using Western BlotWB Suggested Anti-MLL4 Antibody Titration: 5ug/ml Positive Control: HepG2 cell lysateKMT2B is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells
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