Gene Symbol |
PLA2G2D
|
Entrez Gene |
26279
|
Alt Symbol |
PLA2IID, SPLASH, sPLA2-IID, sPLA2S
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
phospholipase A2, group IID
|
Other Description |
GIID sPLA2|group IID secretory phospholipase A2|phosphatidylcholine 2-acylhydrolase 2D|secretory phospholipase A2s|secretory-type PLA, stroma-associated homolog
|
Swissprots |
Q9UNK4 Q9UK01 B1AEL9 A8K2Z1
|
Accessions |
ACA06110 EAW94915 Q9UNK4 AF112982 AAD51390 AF188625 AAF09020 AK026347 AK290406 BAF83095 AK301396 BAG62931 AK310156 AK311903 BAG34844 AM392918 CAL37796 AM392954 CAL37832 AM392977 CAL37855 AM393597 CAL38474 AM393824 CAL38699 BC025706 AAH25706 DC295429 NM_001271814 NP_001258743 NM_012400 NP_036532
|
Function |
PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2- linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.
|
Subcellular Location |
Secreted {ECO:0000305}.
|
Tissue Specificity |
Broadly expressed.
|
Top Pathways |
Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism
|