Gene Symbol | PLA2G2D |
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Entrez Gene | 26279 |
Alt Symbol | PLA2IID, SPLASH, sPLA2-IID, sPLA2S |
Species | Human |
Gene Type | protein-coding |
Description | phospholipase A2, group IID |
Other Description | GIID sPLA2|group IID secretory phospholipase A2|phosphatidylcholine 2-acylhydrolase 2D|secretory phospholipase A2s|secretory-type PLA, stroma-associated homolog |
Swissprots | Q9UNK4 Q9UK01 B1AEL9 A8K2Z1 |
Accessions | ACA06110 EAW94915 Q9UNK4 AF112982 AAD51390 AF188625 AAF09020 AK026347 AK290406 BAF83095 AK301396 BAG62931 AK310156 AK311903 BAG34844 AM392918 CAL37796 AM392954 CAL37832 AM392977 CAL37855 AM393597 CAL38474 AM393824 CAL38699 BC025706 AAH25706 DC295429 NM_001271814 NP_001258743 NM_012400 NP_036532 |
Function | PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2- linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined. |
Subcellular Location | Secreted {ECO:0000305}. |
Tissue Specificity | Broadly expressed. |
Top Pathways | Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism |
group IID sPLA 2 CRISPR/Cas9 KO Plasmid (h) - sc-411908 from Santa Cruz Biotechnology
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group IID sPLA 2 HDR Plasmid (h) - sc-411908-HDR from Santa Cruz Biotechnology
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group IID sPLA 2 Double Nickase Plasmid (h) - sc-411908-NIC from Santa Cruz Biotechnology
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group IID sPLA 2 Double Nickase Plasmid (h2) - sc-411908-NIC-2 from Santa Cruz Biotechnology
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group IID sPLA 2 CRISPR Activation Plasmid (h) - sc-411908-ACT from Santa Cruz Biotechnology
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group IID sPLA 2 CRISPR Activation Plasmid (h2) - sc-411908-ACT-2 from Santa Cruz Biotechnology
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group IID sPLA 2 Lentiviral Activation Particles (h) - sc-411908-LAC from Santa Cruz Biotechnology
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group IID sPLA 2 Lentiviral Activation Particles (h2) - sc-411908-LAC-2 from Santa Cruz Biotechnology
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group IID sPLA 2 siRNA (h) - sc-78911 from Santa Cruz Biotechnology
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group IID sPLA 2 shRNA Plasmid (h) - sc-78911-SH from Santa Cruz Biotechnology
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group IID sPLA 2 shRNA (h) Lentiviral Particles - sc-78911-V from Santa Cruz Biotechnology
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Phospholipase A2 IID RNAi - H00026279-R01 from Novus Biologicals
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MISSION® esiRNA - EHU049761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16890 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16890 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12888 from Sigma-Aldrich
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PLA2G2D siRNA (Human) - CRH8801 from Cohesion Biosciences
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shRNA set against Human PLA2G2D (NM_012400.2) - SHH376760 from Creative biogene
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PLA2G2D shRNA Plasmid (Human) - CHH8801 from Cohesion Biosciences
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PLA2G2D miRNA 3'UTR clone - MiUTR1H-07956 from Creative biogene
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shRNA set against Human PLA2G2D(NM_012400.2) - SHR118852 from Creative biogene
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