| Gene Symbol |
GALNT1
|
| Entrez Gene |
2589
|
| Alt Symbol |
GALNAC-T1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polypeptide N-acetylgalactosaminyltransferase 1
|
| Other Description |
GalNAc transferase 1|UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)|polypeptide GalNAc transferase 1|pp-GaNTase 1|protein-UDP acetylgalactosaminyltransferase 1
|
| Swissprots |
Q9UM86 Q86TJ7 Q10472
|
| Accessions |
AAD14406 EAX01359 EAX01360 Q10472 AJ505952 CAD44535 AK293062 BAF85751 BC038440 AAH38440 BC047746 AAH47746 BM668856 BM838102 CB164572 CK431238 DA991281 DN996147 U41514 AAC50327 X85018 CAA59380 XM_005258239 XP_005258296 NM_020474 NP_065207
|
| Function |
Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. {ECO:0000269|PubMed:9295285}.
|
| Subcellular Location |
Polypeptide N- acetylgalactosaminyltransferase 1: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein.
|
| Tissue Specificity |
Widely expressed. Expressed in all tissues tested. {ECO:0000269|PubMed:7592619}.
|
| Top Pathways |
Mucin type O-Glycan biosynthesis
|
