Gene Symbol | GALNT1 |
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Entrez Gene | 2589 |
Alt Symbol | GALNAC-T1 |
Species | Human |
Gene Type | protein-coding |
Description | polypeptide N-acetylgalactosaminyltransferase 1 |
Other Description | GalNAc transferase 1|UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 1|UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 1 (GalNAc-T1)|polypeptide GalNAc transferase 1|pp-GaNTase 1|protein-UDP acetylgalactosaminyltransferase 1 |
Swissprots | Q9UM86 Q86TJ7 Q10472 |
Accessions | AAD14406 EAX01359 EAX01360 Q10472 AJ505952 CAD44535 AK293062 BAF85751 BC038440 AAH38440 BC047746 AAH47746 BM668856 BM838102 CB164572 CK431238 DA991281 DN996147 U41514 AAC50327 X85018 CAA59380 XM_005258239 XP_005258296 NM_020474 NP_065207 |
Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b and Muc7. {ECO:0000269|PubMed:9295285}. |
Subcellular Location | Polypeptide N- acetylgalactosaminyltransferase 1: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. |
Tissue Specificity | Widely expressed. Expressed in all tissues tested. {ECO:0000269|PubMed:7592619}. |
Top Pathways | Mucin type O-Glycan biosynthesis |
GalNAc-T1 CRISPR/Cas9 KO Plasmid (h) - sc-408128 from Santa Cruz Biotechnology
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GalNAc-T1 HDR Plasmid (h) - sc-408128-HDR from Santa Cruz Biotechnology
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GalNAc-T1 Double Nickase Plasmid (h) - sc-408128-NIC from Santa Cruz Biotechnology
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GalNAc-T1 Double Nickase Plasmid (h2) - sc-408128-NIC-2 from Santa Cruz Biotechnology
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GalNAc-T1 CRISPR Activation Plasmid (h) - sc-408128-ACT from Santa Cruz Biotechnology
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GalNAc-T1 CRISPR Activation Plasmid (h2) - sc-408128-ACT-2 from Santa Cruz Biotechnology
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GalNAc-T1 Lentiviral Activation Particles (h) - sc-408128-LAC from Santa Cruz Biotechnology
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GalNAc-T1 Lentiviral Activation Particles (h2) - sc-408128-LAC-2 from Santa Cruz Biotechnology
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GalNAc-T1 siRNA (h) - sc-75082 from Santa Cruz Biotechnology
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GalNAc-T1 shRNA Plasmid (h) - sc-75082-SH from Santa Cruz Biotechnology
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GalNAc-T1 shRNA (h) Lentiviral Particles - sc-75082-V from Santa Cruz Biotechnology
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Polypeptide GalNac Transferase 1/GALNT1 RNAi - H00002589-R01 from Novus Biologicals
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MISSION® esiRNA - EHU160391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9101 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9101 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10879 from Sigma-Aldrich
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GALNT1 siRNA (Human) - CRH1724 from Cohesion Biosciences
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GALNT1 - MBS8222424 from MyBioSource
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shRNA set against Human GALNT1 (NM_020474.3) - SHH298957 from Creative biogene
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Human GALNT1 siRNA - orb262226 from Biorbyt
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GALNT1 shRNA Plasmid (Human) - CHH1724 from Cohesion Biosciences
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GALNT1 miRNA 3'UTR clone - MiUTR4H-TG03716 from Creative biogene
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