HM13

Gene Symbol HM13
Entrez Gene 81502
Alt Symbol H13, IMP1, IMPAS, IMPAS-1, MSTP086, PSENL3, PSL3, SPP, SPPL1, dJ324O17.1
Species Human
Gene Type protein-coding
Description histocompatibility (minor) 13
Other Description IMP-1|hIMP1|intramembrane protease 1|minor histocompatibility antigen 13|minor histocompatibility antigen H13|presenilin-like protein 3|signal peptide peptidase beta|signal peptide peptidase like 1
Swissprots Q9H111 Q7Z4F2 Q5JWP3 Q540H8 B2RAY5 Q86Y35 Q5JWP5 Q95H87 E1P5L3 Q8TCT9 Q5JWP2 Q15K36 Q5JWP4 Q9H110
Accessions CAF86750 CAJ75919 CBY88428 EAW76435 EAW76436 EAW76437 EAW76438 Q8TCT9 AF172086 AAQ13609 AF483215 AAM22076 AF515663 AAN77099 AJ345029 CAC87790 AJ420895 CAD13132 AK074686 BAC11138 AK075283 BAC11519 AK314410 BAG37032 AY169310 AAO12535 AY169311 AAO12536 AY169312 AAO12537 BC008938 AAH08938 BC008959 AAH08959 BC062595 AAH62595 BI192962 BI552780 BQ707066 BQ890506 BU155406 DA087240 DQ168450 ABA56163 DQ896206 ABM87205 HY026569 XM_005260562 XP_005260619 XM_011529066 XP_011527368 XM_011529067 XP_011527369 XM_011529068 XP_011527370 XM_011529069 XP_011527371 XM_011529070 XP_011527372 XM_011529071 XP_011527373 XM_011529072 XP_011527374 NM_030789 NP_110416 NM_178580 NP_848695 NM_178581 NP_848696 NM_178582 NP_848697
Function Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection (By similarity). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:11714810, PubMed:12077416, PubMed:12145199, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139- dependent manner (PubMed:25239945). {ECO:0000250, ECO:0000269|PubMed:11714810, ECO:0000269|PubMed:12077416, ECO:0000269|PubMed:12145199, ECO:0000269|PubMed:14741365, ECO:0000269|PubMed:25239945}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla. {ECO:0000269|PubMed:12139484, ECO:0000269|PubMed:12972007}.

SPP (N-16) - sc-34950 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
SPP (N-16): sc-34950. Western blot analysis of SPP expression in MIA PaCa-2 whole cell lysate.

SPP (L-15) - sc-34949 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Signal Peptide Peptidase antibody - C-terminal - ab193202 from Abcam

Prices $370.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-Signal Peptide Peptidase antibody - C-terminal (ab193202) at 1/100 dilution + HeLa cell line lysate at 35 µg

Anti-HM13 / IMP-1 / SPP Antibody (aa325-354, AP) - LS-C236292 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HM13 / IMP-1 / SPP Antibody (aa325-354, APC) - LS-C236293 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HM13 / IMP-1 / SPP Antibody (aa325-354, Biotin) - LS-C236294 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HM13 / IMP-1 / SPP Antibody (aa325-354, FITC) - LS-C236295 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HM13 / IMP-1 / SPP Antibody (aa325-354, PE) - LS-C246750 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HM13 / IMP-1 / SPP Antibody (aa325-354, Azide-free, HRP) - LS-C249204 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HM13 / IMP-1 / SPP Antibody (aa324-354) - LS-C321999 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-HM13 / IMP-1 / SPP Antibody (aa325-354) - LS-C164926 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
HM13 Antibody western blot of HeLa cell line lysates (35 ug/lane). The HM13 antibody detected the HM13 protein (arrow).

Anti-HM13 / IMP-1 / SPP Antibody (aa240-289) - LS-C135236 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HM13 antibody LS-C135236 Western blot of Mouse Spleen lysate. Antibody concentration 1 ug/ml.

Anti-HM13 / IMP-1 / SPP Antibody (aa327-377) - LS-C291042 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human SPP by Western Blot of Immunoprecipitates. Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) prepared using NETN buffer from HeLa cells. Antibodies: Affinity purified rabbit anti-SPP antibody used for IP at 6 ug per reaction. SPP was also immunoprecipitated by rabbit anti-SPP antibody BL16569. For blotting immunoprecipitated SPP, was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Signal Peptide Peptidase Antibody - NBP2-32276 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Signal Peptide Peptidase Antibody [NBP2-32276] - Samples: Whole cell lysate (50 ug) prepared using NETN buffer from HeLa, 293T, and Jurkat cells. Antibodies: Affinity purified rabbit anti-SPP antibody NBP2-32276 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Signal Peptide Peptidase Antibody - NBP1-92389 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Signal Peptide Peptidase Antibody [NBP1-92389] Staining of human pancreas shows strong cytoplasmic positivity in exocrine cells.

ANTI-HM13(C-TERMINAL) antibody produced in rabbit - SAB1305126 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-HM13 (C-term): <B>Cat. No. SAB1305126</B>: HM13 Antibody (C-term) western blot analysis in HeLa cell line lysates (35 μg/lane).

Anti-SPP (N-term) antibody produced in rabbit - SAB1300769 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SPP (C-term) antibody produced in rabbit - SAB1300770 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-HM13 antibody produced in rabbit - HPA045089 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-HM13: <B>Cat. No. HPA045089</B>: Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in exocrine cells.

HM13-Antibody-C-term - AP14392b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
HM13 Antibody (C-term) (Cat. #AP14392b) western blot analysis in Hela cell line lysates (35ug/lane).This demonstrates the HM13 antibody detected the HM13 protein (arrow).

HM13 Antibody - C-terminal region (OAAB10690) - OAAB10690 from Aviva Systems Biology

Prices $289.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal

SPP antibody (FITC) - orb3096 from Biorbyt

Prices $315.00
Sizes 100 μg
Host Rabbit
Clonality Polyclonal

HM13 antibody - 70R-17752 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
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