| Gene Symbol | HM13 |
|---|---|
| Entrez Gene | 81502 |
| Alt Symbol | H13, IMP1, IMPAS, IMPAS-1, MSTP086, PSENL3, PSL3, SPP, SPPL1, dJ324O17.1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | histocompatibility (minor) 13 |
| Other Description | IMP-1|hIMP1|intramembrane protease 1|minor histocompatibility antigen 13|minor histocompatibility antigen H13|presenilin-like protein 3|signal peptide peptidase beta|signal peptide peptidase like 1 |
| Swissprots | Q9H111 Q7Z4F2 Q5JWP3 Q540H8 B2RAY5 Q86Y35 Q5JWP5 Q95H87 E1P5L3 Q8TCT9 Q5JWP2 Q15K36 Q5JWP4 Q9H110 |
| Accessions | CAF86750 CAJ75919 CBY88428 EAW76435 EAW76436 EAW76437 EAW76438 Q8TCT9 AF172086 AAQ13609 AF483215 AAM22076 AF515663 AAN77099 AJ345029 CAC87790 AJ420895 CAD13132 AK074686 BAC11138 AK075283 BAC11519 AK314410 BAG37032 AY169310 AAO12535 AY169311 AAO12536 AY169312 AAO12537 BC008938 AAH08938 BC008959 AAH08959 BC062595 AAH62595 BI192962 BI552780 BQ707066 BQ890506 BU155406 DA087240 DQ168450 ABA56163 DQ896206 ABM87205 HY026569 XM_005260562 XP_005260619 XM_011529066 XP_011527368 XM_011529067 XP_011527369 XM_011529068 XP_011527370 XM_011529069 XP_011527371 XM_011529070 XP_011527372 XM_011529071 XP_011527373 XM_011529072 XP_011527374 NM_030789 NP_110416 NM_178580 NP_848695 NM_178581 NP_848696 NM_178582 NP_848697 |
| Function | Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. May play a role in graft rejection (By similarity). May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein. Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (PubMed:11714810, PubMed:12077416, PubMed:12145199, PubMed:14741365). Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139- dependent manner (PubMed:25239945). {ECO:0000250, ECO:0000269|PubMed:11714810, ECO:0000269|PubMed:12077416, ECO:0000269|PubMed:12145199, ECO:0000269|PubMed:14741365, ECO:0000269|PubMed:25239945}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Widely expressed with highest levels in kidney, liver, placenta, lung, leukocytes and small intestine and reduced expression in heart and skeletal muscle. Expressed abundantly in the CNS with highest levels in thalamus and medulla. {ECO:0000269|PubMed:12139484, ECO:0000269|PubMed:12972007}. |
SPP CRISPR/Cas9 KO Plasmid (h) - sc-405271 from Santa Cruz Biotechnology
|
||||||||
SPP HDR Plasmid (h) - sc-405271-HDR from Santa Cruz Biotechnology
|
||||||||
SPP Double Nickase Plasmid (h) - sc-405271-NIC from Santa Cruz Biotechnology
|
||||||||
SPP Double Nickase Plasmid (h2) - sc-405271-NIC-2 from Santa Cruz Biotechnology
|
||||||||
SPP CRISPR Activation Plasmid (h) - sc-405271-ACT from Santa Cruz Biotechnology
|
||||||||
SPP CRISPR Activation Plasmid (h2) - sc-405271-ACT-2 from Santa Cruz Biotechnology
|
||||||||
SPP Lentiviral Activation Particles (h) - sc-405271-LAC from Santa Cruz Biotechnology
|
||||||||
SPP Lentiviral Activation Particles (h2) - sc-405271-LAC-2 from Santa Cruz Biotechnology
|
||||||||
SPP siRNA (h) - sc-45549 from Santa Cruz Biotechnology
|
||||||||
SPP shRNA Plasmid (h) - sc-45549-SH from Santa Cruz Biotechnology
|
||||||||
SPP shRNA (h) Lentiviral Particles - sc-45549-V from Santa Cruz Biotechnology
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN10153 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10153 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR09386 from Sigma-Aldrich
|
||||||||
HM13 siRNA (Human) - CRJ2980 from Cohesion Biosciences
|
||||||||
HM13 - MBS8212447 from MyBioSource
|
||||||||
shRNA set against Human HM13 (NM_178582.1) - SHH313173 from Creative biogene
|
||||||||
shRNA set against Human HM13(NM_178582.1) - SHH124553 from Creative biogene
|
||||||||
shRNA set against Human HM13(NM_178581.1) - SHH124559 from Creative biogene
|
||||||||
shRNA set against Human HM13(NM_030789.2) - SHH124561 from Creative biogene
|
||||||||
shRNA set against Human HM13(NM_178580.1) - SHH124579 from Creative biogene
|
||||||||
shRNA set against Human HM13(NM_178582.1) - SHH124597 from Creative biogene
|
||||||||
shRNA set against Human HM13(NM_178581.1) - SHH124609 from Creative biogene
|
||||||||
Human HM13 siRNA - orb273481 from Biorbyt
|
||||||||
HM13 shRNA Plasmid (Human) - CHJ2980 from Cohesion Biosciences
|