Gene Symbol | TNNC1 |
---|---|
Entrez Gene | 7134 |
Alt Symbol | CMD1Z, CMH13, TN-C, TNC, TNNC |
Species | Human |
Gene Type | protein-coding |
Description | troponin C type 1 (slow) |
Other Description | cardiac troponin C|slow twitch skeletal/cardiac muscle troponin C|troponin C, slow skeletal and cardiac muscles|troponin C1, slow |
Swissprots | P63316 |
Accessions | AAA36772 ADL14491 EAW65226 EAW65227 P63316 AF020769 AAB91994 AJ574625 AK313743 BAG36483 BC030244 AAH30244 CR541865 CAG46663 CR541885 CAG46683 DQ891026 ABM81952 DQ894206 ABM85132 X07897 CAA30736 NM_003280 NP_003271 |
Function | Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. |
Top Pathways | Calcium signaling pathway, Cardiac muscle contraction, Hypertrophic cardiomyopathy (HCM), Dilated cardiomyopathy, Adrenergic signaling in cardiomyocytes |