Gene Symbol | SMNDC1 |
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Entrez Gene | 10285 |
Alt Symbol | SMNR, SPF30, TDRD16C |
Species | Human |
Gene Type | protein-coding |
Description | survival motor neuron domain containing 1 |
Other Description | 30 kDa splicing factor SMNrp|SMN-related protein|splicing factor 30, survival of motor neuron-related|survival motor neuron domain-containing protein 1|survival of motor neuron-related-splicing factor 30|tudor domain containing 16C |
Swissprots | Q5T3K6 O75940 D3DRB1 B2RA27 |
Accessions | EAW49561 EAW49562 EAW49563 EAW49564 O75940 AF083385 AAC64086 AF107463 AAC84148 AK314013 BAG36724 BC011234 AAH11234 BC039110 BQ694303 XM_005269382 XP_005269439 NM_005871 NP_005862 |
Function | Necessary for spliceosome assembly. Overexpression causes apoptosis. {ECO:0000269|PubMed:11331295, ECO:0000269|PubMed:11331595, ECO:0000269|PubMed:9817934}. |
Subcellular Location | Nucleus speckle. Nucleus, Cajal body. Note=Detected in nuclear speckles containing snRNP and in Cajal (coiled) bodies. |
Tissue Specificity | Detected at intermediate levels in skeletal muscle, and at low levels in heart and pancreas. {ECO:0000269|PubMed:9817934}. |
Top Pathways | Spliceosome |
SPF30 CRISPR/Cas9 KO Plasmid (h) - sc-416941 from Santa Cruz Biotechnology
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SPF30 HDR Plasmid (h) - sc-416941-HDR from Santa Cruz Biotechnology
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SPF30 Double Nickase Plasmid (h) - sc-416941-NIC from Santa Cruz Biotechnology
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SPF30 Double Nickase Plasmid (h2) - sc-416941-NIC-2 from Santa Cruz Biotechnology
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SPF30 CRISPR Activation Plasmid (h) - sc-416941-ACT from Santa Cruz Biotechnology
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SPF30 CRISPR Activation Plasmid (h2) - sc-416941-ACT-2 from Santa Cruz Biotechnology
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SPF30 Lentiviral Activation Particles (h) - sc-416941-LAC from Santa Cruz Biotechnology
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SPF30 Lentiviral Activation Particles (h2) - sc-416941-LAC-2 from Santa Cruz Biotechnology
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SPF30 siRNA (h) - sc-63054 from Santa Cruz Biotechnology
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SPF30 shRNA Plasmid (h) - sc-63054-SH from Santa Cruz Biotechnology
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SPF30 shRNA (h) Lentiviral Particles - sc-63054-V from Santa Cruz Biotechnology
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SMNDC1 RNAi - H00010285-R01 from Novus Biologicals
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MISSION® esiRNA - EHU026981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19795 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19795 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07908 from Sigma-Aldrich
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SMNDC1 siRNA (Human) - CRH6966 from Cohesion Biosciences
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SMNDC1 - MBS8206909 from MyBioSource
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shRNA set against Human SMNDC1 (NM_005871.3) - SHH413476 from Creative biogene
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Human SMNDC1 siRNA - orb267468 from Biorbyt
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SMNDC1 shRNA Plasmid (Human) - CHH6966 from Cohesion Biosciences
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SMNDC1 miRNA 3'UTR clone - MiUTR3H-06046 from Creative biogene
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