Gene Symbol | SLC23A1 |
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Entrez Gene | 9963 |
Alt Symbol | SLC23A2, SVCT1, YSPL3 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 23 (ascorbic acid transporter), member 1 |
Other Description | Na(+)/L-ascorbic acid transporter 1|hSVCT1|sodium-dependent vitamin C transporter 1|sodium-dependent vitamin C transporter-1|solute carrier family 23 (nucleobase transporters), member 1|solute carrier family 23 (nucleobase transporters), member 2|solute carrier family 23 member 1|yolk sac permease-like molecule 3 |
Swissprots | Q9UI39 Q8WWB6 O95191 Q9UHI7 Q9UGH4 |
Accessions | AAK97398 EAW62106 Q9UHI7 AF058317 AAC78804 AF098277 AAF22490 AF170911 AAF24759 AI478520 AJ250807 CAC15384 AJ269477 CAB58119 AK092655 BAG52585 AK290789 BAF83478 AK298337 BAG60585 AK300935 BAG62564 BC019225 AAH19225 BC050261 AAH50261 DA385445 XM_005272148 XP_005272205 XM_005272149 XP_005272206 XM_006714741 XP_006714804 XM_011543765 XP_011542067 XM_011543766 XP_011542068 XM_011543767 XP_011542069 XM_011543768 XP_011542070 XM_011543769 XP_011542071 NM_005847 NP_005838 NM_152685 NP_689898 |
Function | Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:19379732}; Multi-pass membrane protein {ECO:0000269|PubMed:19379732}. |
Tissue Specificity | Highly expressed in adult small intestine, kidney, thymus, ovary, colon, prostate and liver, and in fetal kidney, liver and thymus. |
Top Pathways | Vitamin digestion and absorption |
SVCT1 CRISPR/Cas9 KO Plasmid (h) - sc-403006 from Santa Cruz Biotechnology
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SVCT1 HDR Plasmid (h) - sc-403006-HDR from Santa Cruz Biotechnology
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SVCT1 Double Nickase Plasmid (h) - sc-403006-NIC from Santa Cruz Biotechnology
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SVCT1 Double Nickase Plasmid (h2) - sc-403006-NIC-2 from Santa Cruz Biotechnology
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SVCT1 CRISPR Activation Plasmid (h) - sc-403006-ACT from Santa Cruz Biotechnology
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SVCT1 CRISPR Activation Plasmid (h2) - sc-403006-ACT-2 from Santa Cruz Biotechnology
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SVCT1 Lentiviral Activation Particles (h) - sc-403006-LAC from Santa Cruz Biotechnology
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SVCT1 Lentiviral Activation Particles (h2) - sc-403006-LAC-2 from Santa Cruz Biotechnology
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SVCT1 siRNA (h) - sc-41006 from Santa Cruz Biotechnology
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SVCT1 shRNA Plasmid (h) - sc-41006-SH from Santa Cruz Biotechnology
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SVCT1 shRNA (h) Lentiviral Particles - sc-41006-V from Santa Cruz Biotechnology
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SLC23A1 RNAi - H00009963-R02 from Novus Biologicals
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SLC23A2 RNAi - H00009962-R02 from Novus Biologicals
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SLC23A2 RNAi - H00009962-R01 from Novus Biologicals
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SLC23A1 RNAi - H00009963-R01 from Novus Biologicals
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MISSION® esiRNA - EHU082391 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19474 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19474 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03886 from Sigma-Aldrich
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SLC23A1 siRNA (Human) - CRH6701 from Cohesion Biosciences
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SLC23A1 - MBS8202835 from MyBioSource
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shRNA set against Human SLC23A1 (NM_005847.4) - SHH409272 from Creative biogene
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SLC23A1 shRNA Plasmid (Human) - CHH6701 from Cohesion Biosciences
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SLC23A1 miRNA 3'UTR clone - MiUTR3H-06275 from Creative biogene
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SLC23A1 miRNA 3'UTR clone - MiUTR3H-06276 from Creative biogene
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