Gene Symbol | LSG1 |
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Entrez Gene | 55341 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | large 60S subunit nuclear export GTPase 1 |
Other Description | hLsg1|large subunit GTPase 1 homolog |
Swissprots | Q9H089 A6NI18 A0JLT4 Q9NUK8 Q7L9H8 A0PJK3 |
Accessions | EAW78035 EAW78036 EAW78037 EAW78038 EAW78039 Q9H089 AK002163 BAA92116 AK130804 AK225094 AL136897 CAB66831 AM392577 CAL37455 AW748476 BC015042 AAH15042 BC040119 AAH40119 BC058891 BC068500 AAH68500 BQ009975 DA101432 DA414880 NM_018385 NP_060855 |
Function | GTPase required for the XPO1/CRM1-mediated nuclear export of the 60S ribosomal subunit. Probably acts by mediating the release of NMD3 from the 60S ribosomal subunit after export into the cytoplasm (Probable). {ECO:0000305|PubMed:16209721}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:16209721}. Endoplasmic reticulum {ECO:0000269|PubMed:16209721}. Nucleus, Cajal body {ECO:0000269|PubMed:16209721}. Note=Shuttles between the Cajal bodies in the nucleus and the endoplasmic reticulum. |
Top Pathways | Ribosome biogenesis in eukaryotes |
LSG1 CRISPR/Cas9 KO Plasmid (h) - sc-412524 from Santa Cruz Biotechnology
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LSG1 HDR Plasmid (h) - sc-412524-HDR from Santa Cruz Biotechnology
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LSG1 Double Nickase Plasmid (h) - sc-412524-NIC from Santa Cruz Biotechnology
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LSG1 Double Nickase Plasmid (h2) - sc-412524-NIC-2 from Santa Cruz Biotechnology
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LSG1 CRISPR Activation Plasmid (h) - sc-412524-ACT from Santa Cruz Biotechnology
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LSG1 CRISPR Activation Plasmid (h2) - sc-412524-ACT-2 from Santa Cruz Biotechnology
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LSG1 Lentiviral Activation Particles (h) - sc-412524-LAC from Santa Cruz Biotechnology
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LSG1 Lentiviral Activation Particles (h2) - sc-412524-LAC-2 from Santa Cruz Biotechnology
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LSG1 siRNA (h) - sc-78059 from Santa Cruz Biotechnology
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LSG1 shRNA Plasmid (h) - sc-78059-SH from Santa Cruz Biotechnology
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LSG1 shRNA (h) Lentiviral Particles - sc-78059-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU119021 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12791 from Sigma-Aldrich
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LSG1 siRNA (Human) - CRJ0672 from Cohesion Biosciences
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shRNA set against Human LSG1 (NM_018385.2) - SHH335183 from Creative biogene
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Human LSG1 siRNA - orb271173 from Biorbyt
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LSG1 shRNA Plasmid (Human) - CHJ0672 from Cohesion Biosciences
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LSG1 miRNA 3'UTR clone - MiUTR3H-11459 from Creative biogene
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