| Gene Symbol |
LPGAT1
|
| Entrez Gene |
9926
|
| Alt Symbol |
FAM34A, FAM34A1, NET8
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysophosphatidylglycerol acyltransferase 1
|
| Other Description |
acyl-CoA:lysophosphatidylglycerol acyltransferase 1|family with sequence similarity 34, member A
|
| Swissprots |
Q53YL2 Q92604
|
| Accessions |
EAW93407 EAW93408 Q92604 AI264005 AY561706 AAS66979 BC034621 AAH34621 D86960 BAA13196 HQ447838 ADQ32322 XM_005273362 XP_005273419 XM_005273364 XP_005273421 XM_006711695 XP_006711758 XM_011510227 XP_011508529 XM_011510228 XP_011508530 XM_011510229 XP_011508531 NM_014873 NP_055688
|
| Function |
Lysophoshatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor. {ECO:0000269|PubMed:15485873}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:15485873}; Multi-pass membrane protein {ECO:0000269|PubMed:15485873}.
|
| Tissue Specificity |
Highly expressed in liver and placenta. Also expressed in peripheral blood, lung, kidney and brain. Detected at lower levels in colon. {ECO:0000269|PubMed:15485873}.
|
| Top Pathways |
Glycerophospholipid metabolism
|
![Western Blot: LPGAT1 Overexpression Lysate (Adult Normal) [NBL1-12652] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for LPGAT1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5602_LPGAT1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-12652-img0002.jpg)