Gene Symbol | LPGAT1 |
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Entrez Gene | 9926 |
Alt Symbol | FAM34A, FAM34A1, NET8 |
Species | Human |
Gene Type | protein-coding |
Description | lysophosphatidylglycerol acyltransferase 1 |
Other Description | acyl-CoA:lysophosphatidylglycerol acyltransferase 1|family with sequence similarity 34, member A |
Swissprots | Q53YL2 Q92604 |
Accessions | EAW93407 EAW93408 Q92604 AI264005 AY561706 AAS66979 BC034621 AAH34621 D86960 BAA13196 HQ447838 ADQ32322 XM_005273362 XP_005273419 XM_005273364 XP_005273421 XM_006711695 XP_006711758 XM_011510227 XP_011508529 XM_011510228 XP_011508530 XM_011510229 XP_011508531 NM_014873 NP_055688 |
Function | Lysophoshatidylglycerol (LPG) specific acyltransferase that recognizes various acyl-CoAs and LPGs as substrates but demonstrates a clear preference for long chain saturated fatty acyl-CoAs and oleoyl-CoA as acyl donors. Prefers oleoyl-LPG over palmitoyl-LPG as an acyl receptor and oleoyl-CoA over lauroyl-CoA as an acyl donor. {ECO:0000269|PubMed:15485873}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:15485873}; Multi-pass membrane protein {ECO:0000269|PubMed:15485873}. |
Tissue Specificity | Highly expressed in liver and placenta. Also expressed in peripheral blood, lung, kidney and brain. Detected at lower levels in colon. {ECO:0000269|PubMed:15485873}. |
Top Pathways | Glycerophospholipid metabolism |
LPGAT1 CRISPR/Cas9 KO Plasmid (h) - sc-411390 from Santa Cruz Biotechnology
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LPGAT1 HDR Plasmid (h) - sc-411390-HDR from Santa Cruz Biotechnology
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LPGAT1 Double Nickase Plasmid (h) - sc-411390-NIC from Santa Cruz Biotechnology
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LPGAT1 Double Nickase Plasmid (h2) - sc-411390-NIC-2 from Santa Cruz Biotechnology
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LPGAT1 CRISPR Activation Plasmid (h) - sc-411390-ACT from Santa Cruz Biotechnology
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LPGAT1 CRISPR Activation Plasmid (h2) - sc-411390-ACT-2 from Santa Cruz Biotechnology
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LPGAT1 Lentiviral Activation Particles (h) - sc-411390-LAC from Santa Cruz Biotechnology
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LPGAT1 Lentiviral Activation Particles (h2) - sc-411390-LAC-2 from Santa Cruz Biotechnology
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LPGAT1 siRNA (h) - sc-78964 from Santa Cruz Biotechnology
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LPGAT1 shRNA Plasmid (h) - sc-78964-SH from Santa Cruz Biotechnology
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LPGAT1 shRNA (h) Lentiviral Particles - sc-78964-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU010731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN12651 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12651 from Sigma-Aldrich
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LPGAT1 siRNA (Human) - CRH6671 from Cohesion Biosciences
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shRNA set against Human LPGAT1 (NM_014873.2) - SHH333523 from Creative biogene
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Human LPGAT1 siRNA - orb267173 from Biorbyt
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LPGAT1 shRNA Plasmid (Human) - CHH6671 from Cohesion Biosciences
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