MSH6

Gene Symbol	MSH6
Entrez Gene	2956
Alt Symbol	GTBP, GTMBP, HNPCC5, HSAP, p160
Species	Human
Gene Type	protein-coding
Description	mutS homolog 6
Other Description	DNA mismatch repair protein Msh6|G/T mismatch-binding protein|mutS-alpha 160 kDa subunit|sperm-associated protein
Swissprots	Q8TCX4 O43706 P52701 B4E3I4 F5H2F9 O43917 B4DF41 Q9BTB5
Accessions	AAB47425 AAK21215 AAL87401 BAA23673 BAA23674 EAX00208 EAX00209 P52701 AK130683 AK293921 BAG57302 AK304735 BAG65496 AK308392 BC004246 AAH04246 BC071594 BC104665 AAI04666 D89646 BAA23675 DA857066 DQ892898 ABM83824 U28946 AAC50461 U54777 AAB39212 Y16676 CAC79990 XM_005264271 XP_005264328 XM_011532798 XP_011531100 XM_011532799 XP_011531101 XM_011532800 XP_011531102 NM_000179 NP_000170 NM_001281492 NP_001268421 NM_001281493 NP_001268422 NM_001281494 NP_001268423
Function	Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS alpha, which binds to DNA mismatches thereby initiating DNA repair. When bound, MutS alpha bends the DNA helix and shields approximately 20 base pairs, and recognizes single base mismatches and dinucleotide insertion-deletion loops (IDL) in the DNA. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions. The ATPase activity associated with MutS alpha regulates binding similar to a molecular switch: mismatched DNA provokes ADP-->ATP exchange, resulting in a discernible conformational transition that converts MutS alpha into a sliding clamp capable of hydrolysis-independent diffusion along the DNA backbone. This transition is crucial for mismatch re
Subcellular Location	Nucleus {ECO:0000269|PubMed:23622243}. Chromosome {ECO:0000269|PubMed:23622243}. Note=Associates with H3K36me3 via its PWWP domain.
Top Pathways	Mismatch repair, Colorectal cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MSH6 protein fragment - ab152443 from Abcam Category Protein Source Wheat germ Species Human

MSH6 Antibody Blocking Peptide - LS-E15211 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PELP1 Antibody Blocking Peptide - LS-E1277 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PELP1 Antibody Blocking Peptide - LS-E22511 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MSH6 Partial Recombinant Protein - H00002956-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Human MSH6 protein - orb81223 from Biorbyt Category Protein Prices $366.00, $400.00, $612.00 Sizes 5 μg, 2 μg, 10 μg Species Human

Human MSH6 protein - orb246398 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

MSH6 Blocking Peptide - 33R-4146 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MSH6 Blocking Peptide - abx062710 from Abbexa Category Peptide Species Human, Monkey

MSH6 - H00002956-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MSH6 - H00002956-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MSH6 fusion protein - ag12645 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

MSH6 Human - PRPS-752 from NeoScientific Category Protein Prices $351.00, $637.00 Sizes 5 µg, 10 µg Source Escherichia Coli. Species Human

Recombinant Human MSH6 Protein - BP003016-PRO-745 from Syd Labs Category Protein Prices $175.00, $270.00, $490.00 Sizes 2 µg, 5 µg, 10 µg Source E. coli-derived. Species Human

MSH6 - GWB-C2820F from Genway Biotech Category Protein Prices $438.00 Sizes 10 µg

Recombinant Human MutS Homolog 6 - GWB-B3B06C from Genway Biotech Category Protein Prices $245.00, $375.00, $665.00 Sizes 2 μg, 5 μg, 10 μg Species Human

Recombinant Human MSH6, GST-tagged - MSH6-2412H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human MSH6 - MSH6-27948TH from Creative Biomart Category Protein Source E. coli

Recombinant Human MSH6, His-tagged - MSH6-2413H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human MSH6, GST-tagged - MSH6-2414H from Creative Biomart Category Protein Source Wheat Germ Species Human

MSH6 Blocking Peptide - CBP1516 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

MSH6 / GTBP (E371) Peptide - BS2420P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human DNA mismatch repair protein Msh6(MSH6) ,partial - CSB-YP015032HU CSB-BP015032HU CSB-MP015032HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human DNA mismatch repair protein Msh6 - CSB-EP015032HU from Cusabio Category Protein Source E.coli Species Human

GTBP (1220-1360) - sc-4322 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

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