| Gene Symbol |
NASP
|
| Entrez Gene |
4678
|
| Alt Symbol |
FLB7527, PRO1999
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear autoantigenic sperm protein (histone-binding)
|
| Other Description |
histone H1-binding protein|nuclear autoantigenic sperm protein
|
| Swissprots |
Q96A69 Q5T625 D3DQ07 A8K6H2 Q9BTW2 Q5T622 Q53GW5 F5H3J2 B4DQP3 P49321
|
| Accessions |
EAX06964 EAX06965 EAX06966 EAX06967 EAX06968 EAX06969 P49321 AF035191 AAD02006 AK056161 AK092829 AK131249 AK222778 BAD96498 AK222816 BAD96536 AK291637 BAF84326 AK298893 BAG61005 AK299584 BAG61519 AK308001 AL512718 AL571577 AY700118 BC003113 AAH03113 BC009933 AAH09933 BC010105 AAH10105 BC011580 AAH11580 BC053608 AAH53608 BT006757 AAP35403 CK300084 CX781565 DC361634 DQ893275 ABM84201 DQ896606 ABM87605 M97856 AAA36027 XM_005270888 XP_005270945 XM_005270889 XP_005270946 XM_011541509 XP_011539811 NM_001195193 NP_001182122 NM_002482 NP_002473 NM_152298 NP_689511 NM_172164
|
| Function |
Required for DNA replication, normal cell cycle progression and cell proliferation. Forms a cytoplasmic complex with HSP90 and H1 linker histones and stimulates HSP90 ATPase activity. NASP and H1 histone are subsequently released from the complex and translocate to the nucleus where the histone is released for binding to DNA (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus.
|
| Tissue Specificity |
Isoform 1 is testis- and sperm-specific.
|
![Western Blot: NASP Overexpression Lysate (Adult Normal) [NBL1-13483] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for NASP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9006_NASP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13483-img0002.jpg)