| Gene Symbol | Khdrbs1 |
|---|---|
| Entrez Gene | 20218 |
| Alt Symbol | Sam68, p62, p68 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | KH domain containing, RNA binding, signal transduction associated 1 |
| Other Description | GAP-associated tyrosine phosphoprotein p62|KH domain-containing, RNA-binding, signal transduction-associated protein 1|khdrbs1|p21 Ras GTPase-activating protein-associated p62|src associated in mitosis, 68 kDa|src-associated in mitosis 68 kDa protein |
| Swissprots | Q7M4N5 B2KG38 Q3U8T3 Q99M33 Q60735 Q60749 A2ACH3 |
| Accessions | EDL30162 Q60749 AK032935 AK037411 AK044927 AK050520 BAC34303 AK137122 AK146815 AK150687 AK152084 BAE30934 AK199670 AK204780 BB054974 BC002051 AAH02051 BE986307 CJ055187 EL606063 U17046 AAA64997 U17961 AAA86693 XR_376300 NM_011317 NP_035447 NR_045036 |
| Function | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. May not be involved in the nucleocytoplasmic export of unspliced (CTE)- containing RNA species. {ECO:0000269|PubMed:12496368, ECO:0000269|PubMed:7512695, ECO:0000269|PubMed:9315629}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:12496368}. Membrane {ECO:0000269|PubMed:12496368}. |