Gene Symbol | Khdrbs1 |
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Entrez Gene | 20218 |
Alt Symbol | Sam68, p62, p68 |
Species | Mouse |
Gene Type | protein-coding |
Description | KH domain containing, RNA binding, signal transduction associated 1 |
Other Description | GAP-associated tyrosine phosphoprotein p62|KH domain-containing, RNA-binding, signal transduction-associated protein 1|khdrbs1|p21 Ras GTPase-activating protein-associated p62|src associated in mitosis, 68 kDa|src-associated in mitosis 68 kDa protein |
Swissprots | Q7M4N5 B2KG38 Q3U8T3 Q99M33 Q60735 Q60749 A2ACH3 |
Accessions | EDL30162 Q60749 AK032935 AK037411 AK044927 AK050520 BAC34303 AK137122 AK146815 AK150687 AK152084 BAE30934 AK199670 AK204780 BB054974 BC002051 AAH02051 BE986307 CJ055187 EL606063 U17046 AAA64997 U17961 AAA86693 XR_376300 NM_011317 NP_035447 NR_045036 |
Function | Recruited and tyrosine phosphorylated by several receptor systems, for example the T-cell, leptin and insulin receptors. Once phosphorylated, functions as an adapter protein in signal transduction cascades by binding to SH2 and SH3 domain- containing proteins. Role in G2-M progression in the cell cycle. Represses CBP-dependent transcriptional activation apparently by competing with other nuclear factors for binding to CBP. Also acts as a putative regulator of mRNA stability and/or translation rates and mediates mRNA nuclear export. Positively regulates the association of constitutive transport element (CTE)-containing mRNA with large polyribosomes and translation initiation. May not be involved in the nucleocytoplasmic export of unspliced (CTE)- containing RNA species. {ECO:0000269|PubMed:12496368, ECO:0000269|PubMed:7512695, ECO:0000269|PubMed:9315629}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:12496368}. Membrane {ECO:0000269|PubMed:12496368}. |
Sam 68 CRISPR/Cas9 KO Plasmid (m) - sc-422795 from Santa Cruz Biotechnology
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Sam 68 HDR Plasmid (m) - sc-422795-HDR from Santa Cruz Biotechnology
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Sam 68 Double Nickase Plasmid (m) - sc-422795-NIC from Santa Cruz Biotechnology
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Sam 68 Double Nickase Plasmid (m2) - sc-422795-NIC-2 from Santa Cruz Biotechnology
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Sam 68 CRISPR Activation Plasmid (m) - sc-422795-ACT from Santa Cruz Biotechnology
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Sam 68 CRISPR Activation Plasmid (m2) - sc-422795-ACT-2 from Santa Cruz Biotechnology
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Sam 68 Lentiviral Activation Particles (m) - sc-422795-LAC from Santa Cruz Biotechnology
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Sam 68 Lentiviral Activation Particles (m2) - sc-422795-LAC-2 from Santa Cruz Biotechnology
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Sam 68 siRNA (m) - sc-36451 from Santa Cruz Biotechnology
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Sam 68 shRNA Plasmid (m) - sc-36451-SH from Santa Cruz Biotechnology
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Sam 68 shRNA (m) Lentiviral Particles - sc-36451-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU090281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN34255 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND34255 from Sigma-Aldrich
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KHDRBS1 siRNA (Mouse) - CRM3590 from Cohesion Biosciences
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shRNA set against Mouse KHDRBS1 (NM_011317.4) - SHH324391 from Creative biogene
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KHDRBS1 shRNA Plasmid (Mouse) - CHM3590 from Cohesion Biosciences
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