| Gene Symbol |
GFRA3
|
| Entrez Gene |
2676
|
| Alt Symbol |
GDNFR3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GDNF family receptor alpha 3
|
| Other Description |
GDNF family receptor alpha-3|GDNF receptor alpha-3|GDNFR-alpha-3|GFR-alpha-3|GPI-linked receptor|glial cell line-derived neurotrophic factor receptor alpha-3
|
| Swissprots |
Q6UW20 B4DMY9 O60609 B2RA36 Q8IUZ2
|
| Accessions |
CAM55952 EAW62152 EAW62153 O60609 AF051767 AAC24355 AF086292 AK297693 BAG60051 AK314022 BAG36733 AW020606 AY358997 AAQ89356 AY359037 AAQ89396 BC037951 AAH37951 DQ890850 ABM81776 DQ894004 ABM84930 FJ200487 ACO54884 NM_001496 NP_001487
|
| Function |
Receptor for the glial cell line-derived neurotrophic factor, ARTN (artemin). Mediates the artemin-induced autophosphorylation and activation of the RET receptor tyrosine kinase. {ECO:0000269|PubMed:9883723}.
|
| Subcellular Location |
Cell membrane; Lipid-anchor, GPI-anchor.
|
| Tissue Specificity |
Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system. {ECO:0000269|PubMed:9576965}.
|