Gene Symbol | PDHX |
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Entrez Gene | 8050 |
Alt Symbol | DLDBP, E3BP, OPDX, PDX1, proX |
Species | Human |
Gene Type | protein-coding |
Description | pyruvate dehydrogenase complex, component X |
Other Description | dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex|lipoyl-containing pyruvate dehydrogenase complex component X|pyruvate dehydrogenase complex, E3-binding protein subunit|pyruvate dehydrogenase complex, lipoyl-containing component X|pyruvate dehydrogenase protein X component, mitochondrial |
Swissprots | B4DW62 Q96FV8 D3DR11 O60221 E9PBP7 Q99783 E9PB14 O00330 |
Accessions | CAC18649 EAW68158 EAW68159 EAW68160 O00330 AA282215 AF001437 AAB66315 AF052166 AK057123 AK301384 BAG62924 AK312463 BAG35370 BC010389 AAH10389 BI915296 BX648910 DA573433 JF432191 ADZ15408 U79296 AAB50223 U82328 AAC39661 Y13145 CAA73606 XM_011520390 XP_011518692 NM_001135024 NP_001128496 NM_001166158 NP_001159630 NM_003477 NP_003468 |
Function | Required for anchoring dihydrolipoamide dehydrogenase (E3) to the dihydrolipoamide transacetylase (E2) core of the pyruvate dehydrogenase complexes of eukaryotes. This specific binding is essential for a functional PDH complex. |
Subcellular Location | Mitochondrion matrix. |
E3BP CRISPR/Cas9 KO Plasmid (h) - sc-407277 from Santa Cruz Biotechnology
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E3BP HDR Plasmid (h) - sc-407277-HDR from Santa Cruz Biotechnology
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E3BP Double Nickase Plasmid (h) - sc-407277-NIC from Santa Cruz Biotechnology
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E3BP Double Nickase Plasmid (h2) - sc-407277-NIC-2 from Santa Cruz Biotechnology
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E3BP CRISPR Activation Plasmid (h) - sc-407277-ACT from Santa Cruz Biotechnology
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E3BP CRISPR Activation Plasmid (h2) - sc-407277-ACT-2 from Santa Cruz Biotechnology
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E3BP Lentiviral Activation Particles (h) - sc-407277-LAC from Santa Cruz Biotechnology
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E3BP Lentiviral Activation Particles (h2) - sc-407277-LAC-2 from Santa Cruz Biotechnology
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E3BP siRNA (h) - sc-77212 from Santa Cruz Biotechnology
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E3BP shRNA Plasmid (h) - sc-77212-SH from Santa Cruz Biotechnology
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E3BP shRNA (h) Lentiviral Particles - sc-77212-V from Santa Cruz Biotechnology
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PDHX RNAi - H00008050-R01 from Novus Biologicals
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PDX-1/IPF1 RNAi - H00003651-R01 from Novus Biologicals
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MISSION® esiRNA - EHU041971 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16558 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16558 from Sigma-Aldrich
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PDHX siRNA (Human) - CRH5353 from Cohesion Biosciences
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shRNA set against Human PDHX (NM_003477.2) - SHH372756 from Creative biogene
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Human PDHX siRNA - orb265855 from Biorbyt
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PDHX shRNA Plasmid (Human) - CHH5353 from Cohesion Biosciences
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PDHX miRNA 3'UTR clone - MiUTR1H-07738 from Creative biogene
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PDHX miRNA 3'UTR clone - MiUTR3H-10214 from Creative biogene
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PDHX miRNA 3'UTR clone - MiUTR3H-10215 from Creative biogene
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