Gene Symbol | SGCG |
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Entrez Gene | 6445 |
Alt Symbol | A4, DAGA4, DMDA, DMDA1, LGMD2C, MAM, SCARMD2, SCG3, TYPE |
Species | Human |
Gene Type | protein-coding |
Description | sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) |
Other Description | 35 kDa dystrophin-associated glycoprotein|35DAG|35kD dystrophin-associated glycoprotein|gamma sarcoglycan|gamma-SG|gamma-sarcoglycan |
Swissprots | Q32M32 Q5T9J6 Q13326 |
Accessions | AAD13475 EAX08320 EAX08321 Q13326 AK290620 BAF83309 AK316579 BAG38167 BC074777 AAH74777 BC074778 AAH74778 BC109321 AAI09322 DA897096 U34976 AAC50269 XM_005266505 XP_005266562 XM_006719861 XP_006719924 NM_000231 NP_000222 |
Function | Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. |
Subcellular Location | Cell membrane, sarcolemma {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. |
Tissue Specificity | Expressed in skeletal and heart muscle. |
Top Pathways | Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy |
γ-sarcoglycan CRISPR/Cas9 KO Plasmid (h) - sc-402275 from Santa Cruz Biotechnology
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γ-sarcoglycan HDR Plasmid (h) - sc-402275-HDR from Santa Cruz Biotechnology
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γ-sarcoglycan Double Nickase Plasmid (h) - sc-402275-NIC from Santa Cruz Biotechnology
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γ-sarcoglycan Double Nickase Plasmid (h2) - sc-402275-NIC-2 from Santa Cruz Biotechnology
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γ-sarcoglycan CRISPR Activation Plasmid (h) - sc-402275-ACT from Santa Cruz Biotechnology
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γ-sarcoglycan CRISPR Activation Plasmid (h2) - sc-402275-ACT-2 from Santa Cruz Biotechnology
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γ-sarcoglycan Lentiviral Activation Particles (h) - sc-402275-LAC from Santa Cruz Biotechnology
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γ-sarcoglycan Lentiviral Activation Particles (h2) - sc-402275-LAC-2 from Santa Cruz Biotechnology
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γ-sarcoglycan siRNA (h) - sc-43424 from Santa Cruz Biotechnology
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γ-sarcoglycan shRNA Plasmid (h) - sc-43424-SH from Santa Cruz Biotechnology
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γ-sarcoglycan shRNA (h) Lentiviral Particles - sc-43424-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU023801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19222 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19222 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05934 from Sigma-Aldrich
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SGCG siRNA (Human) - CRH4356 from Cohesion Biosciences
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SGCG - MBS8210793 from MyBioSource
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shRNA set against Human SGCG (NM_000231.2) - SHH406208 from Creative biogene
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Human SGCG siRNA - orb264858 from Biorbyt
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SGCG shRNA Plasmid (Human) - CHH4356 from Cohesion Biosciences
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SGCG miRNA 3'UTR clone - MiUTR4H-TG08006 from Creative biogene
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