Gene Symbol | GRIK5 |
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Entrez Gene | 2901 |
Alt Symbol | EAA2, GRIK2, GluK5, KA2 |
Species | Human |
Gene Type | protein-coding |
Description | glutamate receptor, ionotropic, kainate 5 |
Other Description | excitatory amino acid receptor 2|glutamate receptor KA2|glutamate receptor ionotropic, kainate 5 |
Swissprots | Q16478 Q8WWG8 |
Accessions | EAW57090 EAW57091 Q16478 AJ249209 CAC80547 BC037358 BC052975 BC131717 BC168375 AAI68375 BM152516 CA432656 S40369 AAB22591 XM_005258821 XP_005258878 XM_011526862 XP_011525164 XM_011526863 XP_011525165 XM_011526864 XP_011525166 XM_011526865 XP_011525167 XM_011526866 XP_011525168 XM_011526867 XP_011525169 XM_011526868 XP_011525170 XM_011526869 XP_011525171 XM_011526870 XP_011525172 XM_011526871 XP_011525173 XR_935810 NM_001301030 NP_001287959 NM_002088 NP_002079 |
Function | Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists. This receptor binds kainate > quisqualate > domoate > L- glutamate >> AMPA >> NMDA = 1S,3R-ACPD. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. |
Top Pathways | Glutamatergic synapse, Neuroactive ligand-receptor interaction |
KA2 CRISPR/Cas9 KO Plasmid (h) - sc-405272 from Santa Cruz Biotechnology
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KA2 HDR Plasmid (h) - sc-405272-HDR from Santa Cruz Biotechnology
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KA2 Double Nickase Plasmid (h) - sc-405272-NIC from Santa Cruz Biotechnology
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KA2 Double Nickase Plasmid (h2) - sc-405272-NIC-2 from Santa Cruz Biotechnology
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KA2 CRISPR Activation Plasmid (h) - sc-405272-ACT from Santa Cruz Biotechnology
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KA2 CRISPR Activation Plasmid (h2) - sc-405272-ACT-2 from Santa Cruz Biotechnology
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KA2 Lentiviral Activation Particles (h) - sc-405272-LAC from Santa Cruz Biotechnology
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KA2 Lentiviral Activation Particles (h2) - sc-405272-LAC-2 from Santa Cruz Biotechnology
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KA2 siRNA (h) - sc-42495 from Santa Cruz Biotechnology
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KA2 shRNA Plasmid (h) - sc-42495-SH from Santa Cruz Biotechnology
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KA2 shRNA (h) Lentiviral Particles - sc-42495-V from Santa Cruz Biotechnology
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Glutamate Receptor 6 RNAi - H00002898-R02 from Novus Biologicals
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MISSION® esiRNA - EHU157201 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN9684 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9684 from Sigma-Aldrich
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GRIK5 siRNA (Human) - CRH1955 from Cohesion Biosciences
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KA2/GRIK5/Glutamate Receptor KA2 RNAi - H00002901-R01 from Novus Biologicals
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GRIK5 - MBS8210874 from MyBioSource
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Human GRIK5 siRNA - orb262457 from Biorbyt
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GRIK5 shRNA Plasmid (Human) - CHH1955 from Cohesion Biosciences
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GRIK5 miRNA 3'UTR clone - MiUTR3H-03243 from Creative biogene
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