Gene Symbol | UCK1 |
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Entrez Gene | 83549 |
Alt Symbol | URK1 |
Species | Human |
Gene Type | protein-coding |
Description | uridine-cytidine kinase 1 |
Other Description | UCK 1|cytidine monophosphokinase 1|uridine monophosphokinase 1 |
Swissprots | Q9HA47 Q5JT13 Q5JT09 Q96BJ0 Q6IA74 Q5JT12 Q5JT10 |
Accessions | CBX51398 EAW87979 EAW87980 EAW87981 EAW87982 EAW87983 EAW87984 Q9HA47 AA809511 AF125106 AAL75943 AF237290 AAK28324 AF254133 AAK49122 AK022317 BAB14010 AK057848 AK295471 BAG58400 AK307475 BC015547 AAH15547 BC091495 AAH91495 BI770572 CR457281 CAG33562 DA598285 XM_005272224 XP_005272281 XM_005272225 XP_005272282 XM_011519072 XP_011517374 XR_246602 XR_246603 NM_001135954 NP_001129426 NM_001261450 NP_001248379 NM_001261451 NP_001248380 NM_031432 NP_113620 |
Function | Phosphorylates uridine and cytidine to uridine monophosphate and cytidine monophosphate. Does not phosphorylate deoxyribonucleosides or purine ribonucleosides. Can use ATP or GTP as a phosphate donor. Can also phosphorylate cytidine and uridine nucleoside analogs such as 6-azauridine, 5-fluorouridine, 4- thiouridine, 5-bromouridine, N(4)-acetylcytidine, N(4)- benzoylcytidine, 5-fluorocytidine, 2-thiocytidine, 5- methylcytidine, and N(4)-anisoylcytidine. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Drug metabolism - other enzymes, Pyrimidine metabolism |
UCK1 CRISPR/Cas9 KO Plasmid (h) - sc-408541 from Santa Cruz Biotechnology
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UCK1 HDR Plasmid (h) - sc-408541-HDR from Santa Cruz Biotechnology
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UCK1 Double Nickase Plasmid (h) - sc-408541-NIC from Santa Cruz Biotechnology
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UCK1 Double Nickase Plasmid (h2) - sc-408541-NIC-2 from Santa Cruz Biotechnology
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UCK1 CRISPR Activation Plasmid (h) - sc-408541-ACT from Santa Cruz Biotechnology
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UCK1 CRISPR Activation Plasmid (h2) - sc-408541-ACT-2 from Santa Cruz Biotechnology
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UCK1 Lentiviral Activation Particles (h) - sc-408541-LAC from Santa Cruz Biotechnology
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UCK1 Lentiviral Activation Particles (h2) - sc-408541-LAC-2 from Santa Cruz Biotechnology
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UCK1 siRNA (h) - sc-92649 from Santa Cruz Biotechnology
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UCK1 shRNA Plasmid (h) - sc-92649-SH from Santa Cruz Biotechnology
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UCK1 shRNA (h) Lentiviral Particles - sc-92649-V from Santa Cruz Biotechnology
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UCK RNAi - H00083549-R02 from Novus Biologicals
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MISSION® siRNA - SIHK2408 from Sigma-Aldrich
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MISSION® siRNA - SIHK2407 from Sigma-Aldrich
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MISSION® siRNA - SIHK2406 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22437 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22437 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08930 from Sigma-Aldrich
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UCK1 siRNA (Human) - CRJ3128 from Cohesion Biosciences
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UCK1 - MBS8218766 from MyBioSource
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shRNA set against Human UCK1 (NM_031432.2) - SHH439792 from Creative biogene
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Human UCK1 siRNA - orb273629 from Biorbyt
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UCK1 shRNA Plasmid (Human) - CHJ3128 from Cohesion Biosciences
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UCK1 miRNA 3'UTR clone - MiUTR3H-10546 from Creative biogene
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UCK1 miRNA 3'UTR clone - MiUTR3H-10547 from Creative biogene
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