| Gene Symbol |
CSE1L
|
| Entrez Gene |
1434
|
| Alt Symbol |
CAS, CSE1, XPO2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
CSE1 chromosome segregation 1-like (yeast)
|
| Other Description |
cellular apoptosis susceptibility protein|chromosome segregation 1-like protein|exp2|exportin-2|importin-alpha re-exporter
|
| Swissprots |
Q9NTS0 F8W904 B2R5T4 A3RLL6 Q9UPA0 P55060 Q9UP98 E1P5Y0 O75432 Q9H5B7 Q9UP99 Q32M40
|
| Accessions |
AAC35297 EAW75676 EAW75677 P55060 AF053640 AAC35007 AF053641 AAC35008 AF053642 AAC35009 AI018123 AI973168 AK098618 AK225610 AK297270 BAG59743 AK297314 BAG59779 AK298477 BAG60688 AK299549 BAG61494 AK300589 BAG62287 AK307965 AK312306 BAG35231 BC108309 AAI08310 BC109313 AAI09314 BC109314 AAI09315 BG392946 DC402014 EF426455 ABO15009 EU832780 ACE87791 GQ129319 ACT64453 U33286 AAC50367 XM_011528599 XP_011526901 NM_001256135 NP_001243064 NM_001316 NP_001307 NR_045796 NM_177436
|
| Function |
Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269|PubMed:9323134}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
|
| Tissue Specificity |
Highly expressed in proliferating cells.
|
![Western Blot: CAS/Exportin-2 Overexpression Lysate (Adult Normal) [NBP2-10972] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CAS/Exportin-2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1939_CAS-Exportin-2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10972-img0001.jpg)