CSE1L

Gene Symbol	CSE1L
Entrez Gene	1434
Alt Symbol	CAS, CSE1, XPO2
Species	Human
Gene Type	protein-coding
Description	CSE1 chromosome segregation 1-like (yeast)
Other Description	cellular apoptosis susceptibility protein\|chromosome segregation 1-like protein\|exp2\|exportin-2\|importin-alpha re-exporter
Swissprots	Q9NTS0 F8W904 B2R5T4 A3RLL6 Q9UPA0 P55060 Q9UP98 E1P5Y0 O75432 Q9H5B7 Q9UP99 Q32M40
Accessions	AAC35297 EAW75676 EAW75677 P55060 AF053640 AAC35007 AF053641 AAC35008 AF053642 AAC35009 AI018123 AI973168 AK098618 AK225610 AK297270 BAG59743 AK297314 BAG59779 AK298477 BAG60688 AK299549 BAG61494 AK300589 BAG62287 AK307965 AK312306 BAG35231 BC108309 AAI08310 BC109313 AAI09314 BC109314 AAI09315 BG392946 DC402014 EF426455 ABO15009 EU832780 ACE87791 GQ129319 ACT64453 U33286 AAC50367 XM_011528599 XP_011526901 NM_001256135 NP_001243064 NM_001316 NP_001307 NR_045796 NM_177436
Function	Export receptor for importin-alpha. Mediates importin- alpha re-export from the nucleus to the cytoplasm after import substrates (cargos) have been released into the nucleoplasm. In the nucleus binds cooperatively to importin-alpha and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the importin-alpha from the export receptor. CSE1L/XPO2 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. {ECO:0000269\|PubMed:9323134}.
Subcellular Location	Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
Tissue Specificity	Highly expressed in proliferating cells.

CAS (H-2) - sc-271537 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

CAS (H-2): sc-271537. Western blot analysis of CAS expression in 293T whole cell lysate (A) and HeLa nuclear extract (B).

CAS (C-20) - sc-1708 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Western blot analysis of CAS in SW480 (A,B), A549 (C), MOLT-4 (D) and HeLa (E) nuclear extracts. Antibodies tested include CAS (C-20): sc-1708 (A) and CAS (N-19): sc-1709 (B-E).

CAS (H-300) - sc-28233 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

CAS (H-300): sc-28233. Western blot analysis of CAS expression in non-transfected: sc-117752 (A) and human CAS transfected: sc-111651 (B) 293T whole cell lysates and SW480 nuclear extract (C).

CAS (N-19) - sc-1709 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

CAS (N-19): sc-1709. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human liver tumor showing selective cell staining.

CAS (24) - sc-135855 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	50 µg/0.5 ml
Host	Mouse
Clonality	Monoclonal

CAS (24): sc-135855. Western blot analysis of CAS expression in Jurkat whole cell lysate.

Anti-Cellular Apoptosis Susceptibility antibody - ab54674 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Cellular Apoptosis Susceptibility antibody (ab54674) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human colon.

Anti-Cellular Apoptosis Susceptibility antibody - ab27518 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Ab27518, at a dilution of 1/100, staining Cellular Apoptosis Susceptibility protein in formalin fixed paraffin embedded human liver carcinoma tissue section by Immunohistochemistry.

Anti-Cellular Apoptosis Susceptibility antibody - ab52232 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-Cellular Apoptosis Susceptibility antibody (ab52232) at 1/500 dilutionLane 1 : Extracts of 293 cells, untreated.Lane 2 : Extracts of 293 cells, treated with the immunising peptide.

Anti-Cellular Apoptosis Susceptibility antibody [30F12] - ab123553 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	30F12

Anti-Cellular Apoptosis Susceptibility antibody [EPR10326(B)] - ab150432 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR10326(B)

All lanes : Anti-Cellular Apoptosis Susceptibility antibody [EPR10326(B)] (ab150432) at 1/1000 dilutionLane 1 : HeLa cell lysateLane 2 : MOLT4 cell lysateLane 3 : MCF7 cell lysateLane 4 : Ramos cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-Cellular Apoptosis Susceptibility antibody [GT5111] - ab184618 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Mouse
Clonality	Monoclonal
Clone	GT5111

All lanes : Anti-Cellular Apoptosis Susceptibility antibody [GT5111] (ab184618) at 1/1000 dilutionLane 1 : PC-12 whole cell lysateLane 2 : Rat2 whole cell lysateLysates/proteins at 30 µg per lane.

Anti-Cellular Apoptosis Susceptibility antibody, prediluted - ab27519 from Abcam

Prices	$370.00
Sizes	7 ml
Host	Rabbit
Clonality	Polyclonal

Ab27519, prediluted, staining Cellular Apoptosis Susceptibility in formalin fixed paraffin embedded sections by Immunohistochemistry.

Anti-Exportin 2 antibody [EPR10327(B)] - ab151546 from Abcam

Prices	$357.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR10327(B)

All lanes : Anti-Exportin 2 antibody [EPR10327(B)] (ab151546) at 1/1000 dilutionLane 1 : SW480 cell lysateLane 2 : MOLT4 cell lysateLane 3 : HeLa cell lysateLane 4 : 293T cell lysateLane 5 : Ramos cell lysateLane 6 : MCF7 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat anti-rabbit HRP at 1/2000 dilution

Anti-Exportin 2 antibody - N-terminal - ab189180 from Abcam

Prices	$407.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human testis tissue labeling Exportin 2 with ab189180 at 10 µg/ml.

Anti-CSE1L Antibody - LS-C63997 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal

Anti-CSE1L Antibody (aa222-469) - LS-C185515 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

IHC of paraffin-embedded Cal27 Xenograft using CSE1L antibody at 1:500 dilution.

Anti-CSE1L Antibody (N-Terminus) IHC-plus™ - LS-B3346 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CSE1L antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3346 concentration 10 ug/ml.

Anti-CSE1L Antibody (clone 2F4) IHC-plus™ - LS-B6674 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	2F4

Anti-CSE1L antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B6674 concentration 5 ug/ml.

Anti-CSE1L Antibody (clone 3F8) IHC-plus™ - LS-B4307 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	3F8

Anti-CSE1L Antibody - LS-C146954 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

Anti-CSE1L Antibody (N-Terminus) - LS-C112268 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

CSE1L antibody LS-C112268 Western blot of Fetal Brain lysate. Antibody concentration 1 ug/ml.

Anti-CSE1L Antibody (aa872-972, clone 10B2614, Azide-free) - LS-C183544 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	10B2614

Anti-CSE1L Antibody (clone 2218C5a) - LS-C184661 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	2218C5a

Western blot of immunized recombinant protein using CSE1L antibody.

Anti-CSE1L Antibody (clone 3D8) - LS-C104928 from LifeSpan Bioscience

Host	Mouse
Clonality	Monoclonal
Clone	3D8

Immunofluorescence of monoclonal antibody to CSE1L on HeLa cell (antibody concentration 10 ug/ml).

Anti-CSE1L Antibody (aa900-950) - LS-C287358 from LifeSpan Bioscience

Host	Rabbit
Clonality	Polyclonal

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