CDK2

Gene Symbol	CDK2
Entrez Gene	1017
Alt Symbol	CDKN2, p33(CDK2)
Species	Human
Gene Type	protein-coding
Description	cyclin-dependent kinase 2
Other Description	cdc2-related protein kinase|cell division protein kinase 2|p33 protein kinase
Swissprots	O75100 P24941 A8K7C6
Accessions	AAM34794 EAW96856 EAW96857 EAW96858 EAW96859 EAW96860 P24941 AA789250 AA810989 AB012305 BAA32794 AK291941 BAF84630 AK293246 BAG56780 AM393136 CAL38014 BC003065 AAH03065 BJ991087 BT006821 AAP35467 DA814453 DQ890598 ABM92215 DQ893767 ABM84693 M68520 AAA35667 X61622 CAA43807 X62071 CAA43985 XM_011537732 XP_011536034 NM_001290230 NP_001277159 NM_001798 NP_001789 NM_052827 NP_439892
Function	Serine/threonine-protein kinase involved in the control of the cell cycle; essential for meiosis, but dispensable for mitosis. Phosphorylates CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2. Interacts with cyclins A, B1, B3, D, or E. Triggers duplication of centrosomes and DNA. Acts at the G1-S transition to promote the E2F transcriptional program and the initiation of DNA synthesis, and modulates G2 progression; controls the timing of entry into mitosis/meiosis by controlling the subsequent activation of cyclin B/CDK1 by phosphorylation, and coordinates the activation of cyclin B/CDK1 at the centrosome and in the nucleus. Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1
Subcellular Location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, Cajal body. Cytoplasm. Endosome. Note=Localized at the centrosomes in late G2 phase after separation of the centrosomes but before the start of prophase. Nuclear-cytoplasmic trafficking is mediated during the inhibition by 1,25-(OH)(2)D(3).
Top Pathways	Oocyte meiosis, Cell cycle, Measles, Herpes simplex infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human CDK2 + Cyclin A2 full length protein - ab198143 from Abcam Category Protein Prices $1,034.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human CDK2 + Cyclin A2 protein fragment - ab196060 from Abcam Category Protein Prices $1,034.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Cdk2 peptide - ab8009 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Cdk2 full length protein - ab111646 from Abcam Category Protein Prices $402.00 Sizes 50 µg Source E. coli Species Human

Human Cdk2 full length protein - ab125664 from Abcam Category Protein Prices $235.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Human Cdk2 full length protein - ab126917 from Abcam Category Protein Prices $235.00 Sizes 20 µg Source Baculovirus infected sf9 cells Species Human

Human Cdk2 full length protein - ab187421 from Abcam Category Protein Prices $442.00 Sizes 50 µg Source Baculovirus infected insect cells Species Human

Human Cdk2 peptide - ab71917 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Cdk2 peptide - ab71918 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

CDK2 Recombinant Protein - H00001017-P02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

CDK2 Partial Recombinant Protein - H00001017-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Cdk2/Cyclin A2 Recombinant Protein - P4655 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant Human Cdk2/Cyclin A2 Protein - P4642 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Source Insect Species Human

Recombinant Human CDK2 Protein - NBP1-72424 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E. coli Species Human

CDK2 Peptide - P1298 from Novus Biologicals Category Peptide Species Human

CDK2 Peptide - P2523 from Novus Biologicals Category Peptide Species Human

Phospho-Cdk2T160-Antibody-Blocking-peptide - BP3067a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-CDK2T14-Antibody-Blocking-peptide - BP3613a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

CDK2-Antibody-Center-R199-Blocking-Peptide - BP7518c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CDK2-Antibody-C-term-Blocking-Peptide - BP7518b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Biotinylated-Cdk2-T14-Non-phospho-Control-Peptide - SP2013d from Abgent, a WuXi AppTec company Category Peptide Prices $150.00 Sizes 1 mg

Cdk2-T14-Non-phospho-Control-Peptide - SP2013c from Abgent, a WuXi AppTec company Category Peptide Prices $132.00 Sizes 1 mg

Human CDK2 protein - orb49327 from Biorbyt Category Protein Prices $366.00, $706.00, $2,321.00, $3,281.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human CDK2 protein - orb168090 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 2 μg, 10 μg Source E. coli Species Human

CDK2 protein - orb197670 from Biorbyt Category Protein Prices $306.00, $493.00, $638.00 Sizes 10 μg, 50 μg, 100 μg Species Human

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