Gene Symbol |
SLC29A2
|
Entrez Gene |
3177
|
Alt Symbol |
DER12, ENT2, HNP36
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
solute carrier family 29 (equilibrative nucleoside transporter), member 2
|
Other Description |
36 kDa nucleolar protein HNP36|delayed-early response protein 12|equilibrative NBMPR-insensitive nucleoside transporter|equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter|equilibrative nucleoside transporter 2|hydrophobic nucleolar protein, 36 kDa|hydrophobic nucleolar protein, 36kD|nucleoside transporter, ei-type|solute carrier family 29 (nucleoside transporters), member 2|solute carrier family 29 member 2
|
Swissprots |
Q9UPE0 Q14542 Q52M84 B3KPY7 O43530 Q96R00
|
Accessions |
EAW74519 EAW74520 EAW74521 EAW74522 Q14542 AF029358 AAC39526 AF034102 AAB97834 AF401235 AAK92533 AK057041 BAG51849 BC011387 AAH11387 BC093634 AAH93634 BC143335 CB243770 DB124589 DB155519 X86681 CAA60380 XM_011544973 XP_011543275 XM_011544974 XP_011543276 XM_011544975 XP_011543277 XM_011544976 XP_011543278 XM_011544977 XP_011543279 XM_011544978 XP_011543280 XM_011544979 XP_011543281 XM_011544980 XP_011543282 XM_011544981 XP_011543283 XM_011544982 XP_011543284 XR_949900 NM_001300868 NP_001287797 NM_001300869 NP_001287798 NM_001532 NP_001523 NR_125343
|
Function |
Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine. {ECO:0000269|PubMed:9396714}.
|
Subcellular Location |
Basolateral cell membrane {ECO:0000269|PubMed:12527552}; Multi-pass membrane protein {ECO:0000269|PubMed:12527552}. Nucleus membrane {ECO:0000269|PubMed:12527552}; Multi-pass membrane protein {ECO:0000269|PubMed:12527552}. Note=Localized at the basolateral cell membrane in polarized MDCK cells.
|
Tissue Specificity |
Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues. {ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:9396714}.
|