Gene Symbol | SLC29A2 |
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Entrez Gene | 3177 |
Alt Symbol | DER12, ENT2, HNP36 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 29 (equilibrative nucleoside transporter), member 2 |
Other Description | 36 kDa nucleolar protein HNP36|delayed-early response protein 12|equilibrative NBMPR-insensitive nucleoside transporter|equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter|equilibrative nucleoside transporter 2|hydrophobic nucleolar protein, 36 kDa|hydrophobic nucleolar protein, 36kD|nucleoside transporter, ei-type|solute carrier family 29 (nucleoside transporters), member 2|solute carrier family 29 member 2 |
Swissprots | Q9UPE0 Q14542 Q52M84 B3KPY7 O43530 Q96R00 |
Accessions | EAW74519 EAW74520 EAW74521 EAW74522 Q14542 AF029358 AAC39526 AF034102 AAB97834 AF401235 AAK92533 AK057041 BAG51849 BC011387 AAH11387 BC093634 AAH93634 BC143335 CB243770 DB124589 DB155519 X86681 CAA60380 XM_011544973 XP_011543275 XM_011544974 XP_011543276 XM_011544975 XP_011543277 XM_011544976 XP_011543278 XM_011544977 XP_011543279 XM_011544978 XP_011543280 XM_011544979 XP_011543281 XM_011544980 XP_011543282 XM_011544981 XP_011543283 XM_011544982 XP_011543284 XR_949900 NM_001300868 NP_001287797 NM_001300869 NP_001287798 NM_001532 NP_001523 NR_125343 |
Function | Mediates equilibrative transport of purine, pyrimidine nucleosides and the purine base hypoxanthine. Very less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep and draflazine. {ECO:0000269|PubMed:9396714}. |
Subcellular Location | Basolateral cell membrane {ECO:0000269|PubMed:12527552}; Multi-pass membrane protein {ECO:0000269|PubMed:12527552}. Nucleus membrane {ECO:0000269|PubMed:12527552}; Multi-pass membrane protein {ECO:0000269|PubMed:12527552}. Note=Localized at the basolateral cell membrane in polarized MDCK cells. |
Tissue Specificity | Expressed in skeletal muscle, liver, lung, placenta, brain, heart, kidney and ovarian tissues. {ECO:0000269|PubMed:12527552, ECO:0000269|PubMed:9396714}. |
ENT2 CRISPR/Cas9 KO Plasmid (h) - sc-401952 from Santa Cruz Biotechnology
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ENT2 HDR Plasmid (h) - sc-401952-HDR from Santa Cruz Biotechnology
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ENT2 Double Nickase Plasmid (h) - sc-401952-NIC from Santa Cruz Biotechnology
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ENT2 Double Nickase Plasmid (h2) - sc-401952-NIC-2 from Santa Cruz Biotechnology
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ENT2 CRISPR Activation Plasmid (h) - sc-401952-ACT from Santa Cruz Biotechnology
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ENT2 CRISPR Activation Plasmid (h2) - sc-401952-ACT-2 from Santa Cruz Biotechnology
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ENT2 Lentiviral Activation Particles (h) - sc-401952-LAC from Santa Cruz Biotechnology
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ENT2 Lentiviral Activation Particles (h2) - sc-401952-LAC-2 from Santa Cruz Biotechnology
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ENT2 siRNA (h) - sc-60585 from Santa Cruz Biotechnology
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ENT2 shRNA Plasmid (h) - sc-60585-SH from Santa Cruz Biotechnology
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ENT2 shRNA (h) Lentiviral Particles - sc-60585-V from Santa Cruz Biotechnology
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ENT2 RNAi - H00003177-R01 from Novus Biologicals
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MISSION® esiRNA - EHU145531 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19541 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19541 from Sigma-Aldrich
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SLC29A2 siRNA (Human) - CRH2170 from Cohesion Biosciences
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SLC29A2 - MBS8226890 from MyBioSource
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shRNA set against Human Slc29a2 (NM_001532.2) - SHH410160 from Creative biogene
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shRNA set against Human SLC29A2(NM_001532.2) - SHL004982 from Creative biogene
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Human SLC29A2 siRNA - orb262672 from Biorbyt
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SLC29A2 shRNA Plasmid (Human) - CHH2170 from Cohesion Biosciences
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SLC29A2 miRNA 3'UTR clone - MiUTR1H-09510 from Creative biogene
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