| Gene Symbol |
KREMEN2
|
| Entrez Gene |
79412
|
| Alt Symbol |
KRM2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kringle containing transmembrane protein 2
|
| Other Description |
dickkopf receptor 2|kremen protein 2|kringle domain-containing transmembrane protein 2|kringle-containing protein marking the eye and the nose
|
| Swissprots |
B4DXF6 Q9BTP9 Q8NCW0 Q8N2J4 Q8NCW1 Q96GL8 I3L2S2
|
| Accessions |
EAW85445 EAW85446 EAW85447 EAW85448 EAW85449 Q8NCW0 AB086355 BAC00823 AB086356 BAC00824 AB086357 BAC00825 AB086405 BAC00872 AK027669 BAB55281 AK075033 BAC11365 AK223422 BAD97142 AK301953 BAG63368 BC003533 AAH03533 BC009383 AAH09383 DQ896447 ABM87446 NM_001253725 NP_001240654 NM_001253726 NP_001240655 NM_024507 NP_078783 NM_172229 NP_757384 NM_145347 NM_145348
|
| Function |
Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane (By similarity). {ECO:0000250|UniProtKB:Q8K1S7}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|