Gene Symbol | KREMEN2 |
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Entrez Gene | 79412 |
Alt Symbol | KRM2 |
Species | Human |
Gene Type | protein-coding |
Description | kringle containing transmembrane protein 2 |
Other Description | dickkopf receptor 2|kremen protein 2|kringle domain-containing transmembrane protein 2|kringle-containing protein marking the eye and the nose |
Swissprots | B4DXF6 Q9BTP9 Q8NCW0 Q8N2J4 Q8NCW1 Q96GL8 I3L2S2 |
Accessions | EAW85445 EAW85446 EAW85447 EAW85448 EAW85449 Q8NCW0 AB086355 BAC00823 AB086356 BAC00824 AB086357 BAC00825 AB086405 BAC00872 AK027669 BAB55281 AK075033 BAC11365 AK223422 BAD97142 AK301953 BAG63368 BC003533 AAH03533 BC009383 AAH09383 DQ896447 ABM87446 NM_001253725 NP_001240654 NM_001253726 NP_001240655 NM_024507 NP_078783 NM_172229 NP_757384 NM_145347 NM_145348 |
Function | Receptor for Dickkopf protein. Cooperates with Dickkopf to block Wnt/beta-catenin signaling. Forms a ternary complex with Dkk1 and LRP6 and induces rapid endocytosis and removal of the Wnt receptor LRP6 from the plasma membrane (By similarity). {ECO:0000250|UniProtKB:Q8K1S7}. |
Subcellular Location | Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}. |
Kremen-2 CRISPR/Cas9 KO Plasmid (h) - sc-413166 from Santa Cruz Biotechnology
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Kremen-2 HDR Plasmid (h) - sc-413166-HDR from Santa Cruz Biotechnology
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Kremen-2 Double Nickase Plasmid (h) - sc-413166-NIC from Santa Cruz Biotechnology
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Kremen-2 Double Nickase Plasmid (h2) - sc-413166-NIC-2 from Santa Cruz Biotechnology
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Kremen-2 CRISPR Activation Plasmid (h) - sc-413166-ACT from Santa Cruz Biotechnology
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Kremen-2 CRISPR Activation Plasmid (h2) - sc-413166-ACT-2 from Santa Cruz Biotechnology
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Kremen-2 Lentiviral Activation Particles (h) - sc-413166-LAC from Santa Cruz Biotechnology
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Kremen-2 Lentiviral Activation Particles (h2) - sc-413166-LAC-2 from Santa Cruz Biotechnology
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Kremen-2 siRNA (h) - sc-93191 from Santa Cruz Biotechnology
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Kremen-2 shRNA Plasmid (h) - sc-93191-SH from Santa Cruz Biotechnology
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Kremen-2 shRNA (h) Lentiviral Particles - sc-93191-V from Santa Cruz Biotechnology
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Kremen-2 RNAi - H00079412-R02 from Novus Biologicals
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Kremen-2 RNAi - H00079412-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN11351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11351 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04328 from Sigma-Aldrich
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KREMEN2 siRNA (Human) - CRJ2380 from Cohesion Biosciences
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shRNA set against Human KREMEN2 (NM_024507.3) - SHH327155 from Creative biogene
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Human KREMEN2 siRNA - orb272881 from Biorbyt
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KREMEN2 shRNA Plasmid (Human) - CHJ2380 from Cohesion Biosciences
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