Akt2

Gene Symbol	Akt2
Entrez Gene	11652
Alt Symbol	2410016A19Rik, AW554154, PKB, PKBbeta
Species	Mouse
Gene Type	protein-coding
Description	thymoma viral proto-oncogene 2
Other Description	PKB beta|RAC-PK-beta|RAC-beta serine/threonine protein kinase|RAC-beta serine/threonine-protein kinase|protein kinase Akt-2|protein kinase B beta|protein kinase B, beta
Swissprots	Q60823
Accessions	EDL24175 EDL24176 Q60823 AK010511 AK028871 BAC26162 AK083753 AK144217 BAE25779 AK158792 BAE34668 AK163678 AK182878 AK185382 AK188476 AK191996 AK192065 AK194817 AK197083 AK197364 AK201443 AK212175 AK219231 BB862964 BC026151 AAH26151 BC028759 BC040377 AAH40377 CJ311436 U22445 AAA83557 XM_006539477 XP_006539540 XM_006539478 XP_006539541 XM_006539480 XP_006539543 XM_006539481 XP_006539544 XM_006539482 XP_006539545 XM_006539483 XP_006539546 XM_011250418 XP_011248720 NM_001110208 NP_001103678 NM_007434 NP_031460
Function	AKT2 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinases, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glyc
Subcellular Location	Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N- terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3. {ECO:0000250}.
Top Pathways	Apoptosis, Tight junction, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse-Akt2-Antibody-N-term - AP13906a from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

AKT2 antibody - GTX128457 from GeneTex Prices $119.00 Sizes 25 μl

Mouse Akt2 Antibody - N-terminal region (OAAB10204) - OAAB10204 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Akt2 antibody - 70R-35316 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Akt2 antibody (Ser474) - 70R-36653 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Akt antibody - 70R-30854 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Akt antibody - 70R-34608 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Akt antibody - 70R-30638 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Akt antibody (Tyr326) - 70R-33432 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Akt antibody (Ser124) - 70R-30855 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Akt antibody (Thr450) - 70R-30853 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Akt2 antibody (Ser474) - 70R-37204 from Fitzgerald Prices $295.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Akt antibody - 70R-33433 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Akt antibody - 70R-30856 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

AKT2 antibody - 70R-37591 from Fitzgerald Prices $225.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Akt antibody - 70R-30636 from Fitzgerald Prices $275.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Rabbit Anti-Mouse Akt2 (N-term) - 102-12214 from RayBiotech Host Rabbit

Akt2 antibody (N-term) - STJ43519 from St John's Laboratory Ltd Host Rabbit Clonality Polyclonal Clone RB34169

Akt2, gamma, Polyclonal Antibody - MBS615730 from MyBioSource Prices $725.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

AKT antibody - 70R-51440 from Fitzgerald Prices $395.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AKT2 antibody - 70R-49358 from Fitzgerald Prices $395.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AKT antibody - 70R-49356 from Fitzgerald Prices $395.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AKT antibody - 70R-49354 from Fitzgerald Prices $395.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

AKT antibody - 70R-49357 from Fitzgerald Prices $395.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Akt2, Polyclonal Antibody - MBS9213803 from MyBioSource Prices $155.00, $340.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

Search more