| Gene Symbol |
Akt2
|
| Entrez Gene |
11652
|
| Alt Symbol |
2410016A19Rik, AW554154, PKB, PKBbeta
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
thymoma viral proto-oncogene 2
|
| Other Description |
PKB beta|RAC-PK-beta|RAC-beta serine/threonine protein kinase|RAC-beta serine/threonine-protein kinase|protein kinase Akt-2|protein kinase B beta|protein kinase B, beta
|
| Swissprots |
Q60823
|
| Accessions |
EDL24175 EDL24176 Q60823 AK010511 AK028871 BAC26162 AK083753 AK144217 BAE25779 AK158792 BAE34668 AK163678 AK182878 AK185382 AK188476 AK191996 AK192065 AK194817 AK197083 AK197364 AK201443 AK212175 AK219231 BB862964 BC026151 AAH26151 BC028759 BC040377 AAH40377 CJ311436 U22445 AAA83557 XM_006539477 XP_006539540 XM_006539478 XP_006539541 XM_006539480 XP_006539543 XM_006539481 XP_006539544 XM_006539482 XP_006539545 XM_006539483 XP_006539546 XM_011250418 XP_011248720 NM_001110208 NP_001103678 NM_007434 NP_031460
|
| Function |
AKT2 is one of 3 closely related serine/threonine- protein kinases (AKT1, AKT2 and AKT3) called the AKT kinases, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT is responsible of the regulation of glucose uptake by mediating insulin-induced translocation of the SLC2A4/GLUT4 glucose transporter to the cell surface. Phosphorylation of PTPN1 at 'Ser-50' negatively modulates its phosphatase activity preventing dephosphorylation of the insulin receptor and the attenuation of insulin signaling. Phosphorylation of TBC1D4 triggers the binding of this effector to inhibitory 14-3-3 proteins, which is required for insulin-stimulated glucose transport. AKT regulates also the storage of glucose in the form of glyc
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=Localizes within both nucleus and cytoplasm of proliferative primary myoblasts and mostly within the nucleus of differentiated primary myoblasts. By virtue of the N- terminal PH domain, is recruited to sites of the plasma membrane containing increased PI(3,4,5)P3 or PI(3,4)P2, cell membrane targeting is also facilitared by interaction with CLIP3. {ECO:0000250}.
|
| Top Pathways |
Apoptosis, Tight junction, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway
|