NPAS2
| Gene Symbol | NPAS2 |
|---|---|
| Entrez Gene | 4862 |
| Alt Symbol | MOP4, PASD4, bHLHe9 |
| Species | Human |
| Gene Type | protein-coding |
| Description | neuronal PAS domain protein 2 |
| Other Description | PAS domain-containing protein 4|basic-helix-loop-helix-PAS protein MOP4|class E basic helix-loop-helix protein 9|member of PAS protein 4|member of PAS superfamily 4|neuronal PAS domain-containing protein 2|neuronal PAS2 |
| Swissprots | Q99743 Q99629 Q86V96 Q53SQ3 Q4ZFV9 |
| Accessions | AAX88966 AAY14822 ABM64214 EAX01830 EAX01831 EAX01832 EAX01833 EAX01834 EAX01835 Q99743 AK026791 BAB15554 AK091939 AK095806 AK128586 AK226093 AK294733 BAH11862 BC028107 AAH28107 BC035412 BC051351 AAH51351 BC072383 AAH72383 BM724652 BX640699 KJ534892 AHW56532 U51625 AAC51211 U77970 AAB47250 XM_005263953 XP_005264010 XM_005263954 XP_005264011 XM_005263957 XP_005264014 XM_005263959 XP_005264016 XM_005263960 XP_005264017 XM_005263961 XP_005264018 XM_011511242 XP_011509544 XM_011511243 XP_011509545 XR_922928 NM_002518 NP_002509 |
| Function | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:14645221}. |
| Top Pathways | Circadian rhythm |
NPAS2 CRISPR/Cas9 KO Plasmid (h) - sc-405236 from Santa Cruz Biotechnology
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NPAS2 HDR Plasmid (h) - sc-405236-HDR from Santa Cruz Biotechnology
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NPAS2 Double Nickase Plasmid (h) - sc-405236-NIC from Santa Cruz Biotechnology
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NPAS2 Double Nickase Plasmid (h2) - sc-405236-NIC-2 from Santa Cruz Biotechnology
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NPAS2 CRISPR Activation Plasmid (h) - sc-405236-ACT from Santa Cruz Biotechnology
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NPAS2 CRISPR Activation Plasmid (h2) - sc-405236-ACT-2 from Santa Cruz Biotechnology
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NPAS2 Lentiviral Activation Particles (h) - sc-405236-LAC from Santa Cruz Biotechnology
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NPAS2 Lentiviral Activation Particles (h2) - sc-405236-LAC-2 from Santa Cruz Biotechnology
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NPAS2 siRNA (h) - sc-38169 from Santa Cruz Biotechnology
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NPAS2 shRNA Plasmid (h) - sc-38169-SH from Santa Cruz Biotechnology
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NPAS2 shRNA (h) Lentiviral Particles - sc-38169-V from Santa Cruz Biotechnology
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NPAS2 RNAi - H00004862-R01 from Novus Biologicals
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MISSION® esiRNA - EHU079671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15435 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15435 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00011 from Sigma-Aldrich
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NPAS2 siRNA (Human) - CRH3233 from Cohesion Biosciences
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shRNA set against Human NPAS2 (NM_002518.3) - SHH354016 from Creative biogene
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shRNA set against Human NPAS2(NM_002518.3) - SHR017286 from Creative biogene
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Human NPAS2 siRNA - orb263735 from Biorbyt
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NPAS2 shRNA Plasmid (Human) - CHH3233 from Cohesion Biosciences
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NPAS2 miRNA 3'UTR clone - MiUTR1H-06868 from Creative biogene
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