| Gene Symbol | UBXN1 |
|---|---|
| Entrez Gene | 51035 |
| Alt Symbol | 2B28, SAKS1, UBXD10 |
| Species | Human |
| Gene Type | protein-coding |
| Description | UBX domain protein 1 |
| Other Description | SAPK substrate protein 1|UBA/UBX 33.3 kDa protein|UBX domain-containing protein 1 |
| Swissprots | Q9BV93 Q9BVV5 Q04323 |
| Accessions | CAF06446 CAF06447 CAH05541 CAH05542 EAW74061 EAW74062 EAW74063 EAW74064 EAW74065 EAW74066 EAW74067 Q04323 AI498746 AK054832 BAG51430 AK297856 BAG60188 AK300542 BAG62250 AK303471 BAG64510 AK316012 BAH14383 BC000902 AAH00902 BC001372 AAH01372 BC032689 AAH32689 BC040129 AAH40129 BI855821 BP329601 GQ129328 ACT64462 HQ448734 ADQ33212 M68864 AAA36396 XM_005274033 XP_005274090 XM_011545090 XP_011543392 NM_001286077 NP_001273006 NM_001286078 NP_001273007 NM_015853 NP_056937 |
| Function | Ubiquitin-binding protein that interacts with the BRCA1- BARD1 heterodimer, and regulates its activity. Specifically binds 'Lys-6'-linked polyubiquitin chains. Interaction with autoubiquitinated BRCA1, leads to inhibit the E3 ubiquitin-protein ligase activity of the BRCA1-BARD1 heterodimer. Component of a complex required to couple deglycosylation and proteasome-mediated degradation of misfolded proteins in the endoplasmic reticulum that are retrotranslocated in the cytosol. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
UBX domain protein 1, ELISA Kit - MBS9333714 from MyBioSource
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Human UBXN1 ELISA Kit - E101987 from Biobool
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