| Gene Symbol |
EPHA6
|
| Entrez Gene |
285220
|
| Alt Symbol |
EHK-2, EHK2, EK12, EPA6, HEK12, PRO57066
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
EPH receptor A6
|
| Other Description |
EPH homology kinase 2|EPH-like kinase 12|ephrin receptor EphA6|ephrin type-A receptor 6
|
| Swissprots |
Q9UF33 D6RAL5
|
| Accessions |
CBH19275 EAW79885 Q9UF33 AK092565 BAG52574 AK302040 BAG63434 AK302080 BAG63468 AK310249 AL133666 CAB63775 AY358738 AAQ89098 BC031881 BC067287 BC156733 AAI56734 BX099374 DA385338 DC398430 DN991634 DR731365 DV080244 XM_006713592 XP_006713655 XM_011512705 XP_011511007 XM_011512706 XP_011511008 XM_011512707 XP_011511009 XR_924126 XR_924127 NM_001080448 NP_001073917 NM_001278300 NP_001265229 NM_001278301 NP_001265230 NM_173655 NP_775926
|
| Function |
Receptor tyrosine kinase which binds promiscuously GPI- anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Expressed in brain and testis. {ECO:0000269|PubMed:14726470}.
|
| Top Pathways |
Axon guidance
|
![Western Blot: EPH Receptor A6 Overexpression Lysate (Adult Normal) [NBL1-10291] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for EPH Receptor A6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9323_EPH%2520Receptor%2520A6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10291-img0002.jpg)