| Gene Symbol |
MGARP
|
| Entrez Gene |
84709
|
| Alt Symbol |
C4orf49, CESP-1, HUMMR, OSAP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitochondria-localized glutamic acid-rich protein
|
| Other Description |
corneal endothelium-specific protein 1|hypoxia up-regulated mitochondrial movement regulator protein|ovary-specific acidic protein|protein MGARP
|
| Swissprots |
Q8TDB4 Q9BZC3
|
| Accessions |
EAX05122 Q8TDB4 AF329088 AAG59896 AF484960 AAM09685 BC037987 BC104173 AAI04174 BC104174 AAI04175 NM_032623 NP_116012
|
| Function |
Plays a role in the trafficking of mitochondria along microtubules. Regulates the kinesin-mediated axonal transport of mitochondria to nerve terminals along microtubules during hypoxia. Participates in the translocation of TRAK2/GRIF1 from the cytoplasm to the mitochondrion. Also plays a role in steroidogenesis through maintenance of mitochondrial abundance and morphology (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Mitochondrion {ECO:0000269|PubMed:16565373, ECO:0000269|PubMed:21447634}. Mitochondrion outer membrane {ECO:0000250}; Single-pass type IV membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes with RHOT1, RHOT2, TRAK1 and TRAK2 at the mitochondrion. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the brain, adrenal gland and corneal endothelium (CE). Expressed in steroid-producing cells of the ovary and testis (at protein level). Expressed in steroid- producing cells of the ovary and testis. Weakly expressed in placenta. Expressed in corneal endothelial cells. {ECO:0000269|PubMed:12036975, ECO:0000269|PubMed:12770732, ECO:0000269|PubMed:16565373, ECO:0000269|PubMed:19325000, ECO:0000269|PubMed:19528298}.
|