| Gene Symbol | ARG2 |
|---|---|
| Entrez Gene | 384 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | arginase 2 |
| Other Description | L-arginine amidinohydrolase|L-arginine ureahydrolase|arginase, type II|arginase-2, mitochondrial|kidney arginase|kidney-type arginase|non-hepatic arginase|nonhepatic arginase|type II arginase |
| Swissprots | Q6FHY8 P78540 B2R690 |
| Accessions | CBX47614 EAW80943 EAW80944 P78540 AK312484 BAG35387 AL135439 AY074489 AAL71548 BC001350 AAH01350 BC008464 AAH08464 BC029050 AAH29050 CR536550 CAG38787 D86724 BAA13158 U75667 AAB39855 U82256 AAC51664 NM_001172 NP_001163 |
| Function | May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. {ECO:0000269|PubMed:12859189}. |
| Subcellular Location | Mitochondrion. |
| Tissue Specificity | Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas. |
| Top Pathways | Amoebiasis, Arginine and proline metabolism, Biosynthesis of amino acids |