Gene Symbol | ARG2 |
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Entrez Gene | 384 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | arginase 2 |
Other Description | L-arginine amidinohydrolase|L-arginine ureahydrolase|arginase, type II|arginase-2, mitochondrial|kidney arginase|kidney-type arginase|non-hepatic arginase|nonhepatic arginase|type II arginase |
Swissprots | Q6FHY8 P78540 B2R690 |
Accessions | CBX47614 EAW80943 EAW80944 P78540 AK312484 BAG35387 AL135439 AY074489 AAL71548 BC001350 AAH01350 BC008464 AAH08464 BC029050 AAH29050 CR536550 CAG38787 D86724 BAA13158 U75667 AAB39855 U82256 AAC51664 NM_001172 NP_001163 |
Function | May play a role in the regulation of extra-urea cycle arginine metabolism and also in down-regulation of nitric oxide synthesis. Extrahepatic arginase functions to regulate L-arginine bioavailability to NO synthase. Since NO synthase is found in the penile corpus cavernosum smooth muscle, the clitoral corpus cavernosum and the vagina, arginase II plays a role in both male and female sexual arousal. It is therefore a potential target for the treatment of male and female sexual arousal disorders. {ECO:0000269|PubMed:12859189}. |
Subcellular Location | Mitochondrion. |
Tissue Specificity | Expressed most strongly in kidney and prostate, much less strongly in the brain, skeletal muscle, placenta, lung, mammary gland, macrophage, uterus, testis and gut, but apparently not in the liver, heart and pancreas. |
Top Pathways | Amoebiasis, Arginine and proline metabolism, Biosynthesis of amino acids |
Human Arg2 full length protein - ab97349 from Abcam
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Human Arg2 full length protein - ab172173 from Abcam
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Human Arg2 full length protein - ab116403 from Abcam
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ARG2 / Arginase 2 Antibody Blocking Peptide - LS-E19652 from LifeSpan Bioscience
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ARG2 / Arginase 2 Antibody Blocking Peptide - LS-E19651 from LifeSpan Bioscience
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ARG2 Recombinant Protein - H00000384-P01 from Novus Biologicals
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Recombinant Human ARG2 Protein - NBP1-45256 from Novus Biologicals
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ARG2-Antibody-C-term-Blocking-peptide - BP12496b from Abgent, a WuXi AppTec company
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ARG2 Protein Lysate (APL10232) - APL10232 from Aviva Systems Biology
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ARG2 Protein Lysate (APL10233) - APL10233 from Aviva Systems Biology
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ARG2 Protein (OPPA02259) - OPPA02259 from Aviva Systems Biology
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Human ARG2 protein - orb90036 from Biorbyt
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ARG2 peptide - orb216938 from Biorbyt
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ARG2 Blocking Peptide - 33R-5425 from Fitzgerald
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ARG2 protein (His tag) - 80R-1354 from Fitzgerald
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Arginase 2 Blocking Peptide - 33R-8306 from Fitzgerald
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Arginase 2 Blocking Peptide - abx062269 from Abbexa
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Human Arginase II Protein - abx065455 from Abbexa
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Arginase-2 (23-354, His-tag) - AR09528PU-L from Acris Antibodies
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Arginase-2 (23-354, His-tag) - AR09528PU-N from Acris Antibodies
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Arginase-2 - H00000384-P01-10 from Acris Antibodies
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Arginase-2 - H00000384-P01-25 from Acris Antibodies
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ARG2, 23-354aa, Human, His tag, E.coli - 01-1835-2 from ARP American Research Products
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Arginase II (Arg2), Human - 20-8845 from ARP American Research Products
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Kidney-type arginase, ARG2, Human, Recombinant - 19-CE71 from ARP American Research Products
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