ALOX15

Gene Symbol	ALOX15
Entrez Gene	246
Alt Symbol	12-LOX, 15-LOX-1, 15LOX-1
Species	Human
Gene Type	protein-coding
Description	arachidonate 15-lipoxygenase
Other Description	12/15-lipoxygenase|15-LOX|15-lipooxygenase-1|arachidonate 12-lipoxygenase, leukocyte-type|arachidonate omega-6 lipoxygenase
Swissprots	P16050 Q99657 B7ZA11 A8K2P4 Q8N6R7
Accessions	AAB49305 AAC52118 AAR84235 EAW90427 EAW90428 P16050 AK290309 BAF82998 AK296792 BAH12431 AK296821 BAH12437 AK296904 BAH12452 AK312557 BAG35454 AK316126 BAH14497 BC029032 AAH29032 M23892 AAA36182 M95923 AAA35482 NM_001140 NP_001131
Function	Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Converts arachidonic acid into 12- hydroperoxyeicosatetraenoic acid/12-HPETE and 15- hydroperoxyeicosatetraenoic acid/15-HPETE. Also converts linoleic acid to 13-hydroperoxyoctadecadienoic acid. May also act on (12S)- hydroperoxyeicosatetraenoic acid/(12S)-HPETE to produce hepoxilin A3. Probably plays an important role in the immune and inflammatory responses. Through the oxygenation of membrane-bound phosphatidylethanolamine in macrophages may favor clearance of apoptotic cells during inflammation by resident macrophages and prevent an autoimmune response associated with the clearance of apoptotic cells by inflammatory monocytes. In parallel, may regulate actin polymerization which is crucial for several biological processes, including macrophage function. May also regulate macrophage function throug
Subcellular Location	Cytoplasm, cytosol. Cell membrane; Peripheral membrane protein. Lipid droplet. Note=Predominantly cytosolic; becomes enriched at membranes upon calcium binding. Translocates from the cytosol to the plasma membrane when stimulated by IL13/interleukin-13 and in macrophages binding apoptotic cells.
Tissue Specificity	Detected in monocytes and eosinophils (at protein level). Expressed in airway epithelial cells. {ECO:0000269|PubMed:21831839, ECO:0000269|PubMed:9414270}.
Top Pathways	Arachidonic acid metabolism, Linoleic acid metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

15-LO (B-7) - sc-133085 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

15-LO (H-235) - sc-32940 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

15-LO (V-17) - sc-27354 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-15 Lipoxygenase 1 antibody - ab131116 from Abcam Prices $376.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-15 Lipoxygenase 1 antibody - ab80495 from Abcam Prices $376.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-15 Lipoxygenase 1 antibody - ab195432 from Abcam Prices $359.00 Sizes 50 µl Host Sheep Clonality Polyclonal

Anti-15 Lipoxygenase 1 antibody - ab54772 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-15 Lipoxygenase 1 antibody [3D8] - ab110100 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 3D8

Anti-15 Lipoxygenase 1 antibody [3G8] - ab119774 from Abcam Prices $384.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 3G8

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa539-588) - LS-C111783 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa170-312, Biotin) - LS-C299109 from LifeSpan Bioscience Prices $405.00 Sizes 200 µg Host Mouse Clonality Monoclonal

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa170-312, Biotin) - LS-C300672 from LifeSpan Bioscience Prices $435.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa170-312, FITC) - LS-C304281 from LifeSpan Bioscience Prices $455.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa170-312, FITC) - LS-C304832 from LifeSpan Bioscience Prices $425.00 Sizes 200 µg Host Mouse Clonality Monoclonal

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa170-312) - LS-C292377 from LifeSpan Bioscience Prices $395.00 Sizes 200 µg Host Mouse Clonality Monoclonal

Anti-ALOX15 / 15-Lipoxygenase Antibody (clone 8C5) - LS-C173721 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 8C5

Anti-ALOX15 / 15-Lipoxygenase Antibody - LS-C309426 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa170-312) - LS-C292930 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ALOX15 / 15-Lipoxygenase Antibody IHC-plus™ - LS-B7902 from LifeSpan Bioscience Prices $395.00 Sizes 1 ea Host Sheep Clonality Polyclonal

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa610-643) - LS-C99452 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-ALOX15 / 15-Lipoxygenase Antibody (clone 3D8) IHC-plus™ - LS-B4278 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Mouse Clonality Monoclonal Clone 3D8

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa2-337) - LS-C343940 from LifeSpan Bioscience Prices $325.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-ALOX15 / 15-Lipoxygenase Antibody (clone 2G3) - LS-C173699 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 2G3

Anti-ALOX15 / 15-Lipoxygenase Antibody (clone 7H6) IHC-plus™ - LS-B12236 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Mouse Clonality Monoclonal Clone 7H6

Anti-ALOX15 / 15-Lipoxygenase Antibody (aa482-494) IHC-plus™ - LS-B6689 from LifeSpan Bioscience Prices $395.00 Sizes 50 µg Host Goat Clonality Polyclonal

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