| Gene Symbol |
C11orf30
|
| Entrez Gene |
56946
|
| Alt Symbol |
EMSY, GL002
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
chromosome 11 open reading frame 30
|
| Other Description |
protein EMSY
|
| Swissprots |
Q9NRH0 Q9H8I9 Q17RM7 B7ZKT8 Q8TE50 Q7Z589 Q8NBU6 Q4G109 B7ZKU2 B7ZKU0
|
| Accessions |
CCQ43627 EAW74996 EAW74997 EAW74998 EAW74999 EAW75000 Q7Z589 AF226047 AAF86947 AI275430 AJ430203 CAD22881 AK023651 BAB14627 AK125114 BAG54147 AK126030 BAG54280 AK300400 BAG62131 AK304043 BAG64954 AK304106 BAG65009 AK309621 AY070433 AAL65260 BC021688 BC029375 AAH29375 BC033404 AAH33404 BC117265 AAI17266 BC143370 AAI43371 BC143374 AAI43375 BC143376 AAI43377 BG722092 BX647398 XM_005274112 XP_005274169 XM_006718637 XP_006718700 XM_006718638 XP_006718701 XM_006718639 XP_006718702 XM_011545173 XP_011543475 XM_011545174 XP_011543476 XM_011545175 XP_011543477 XM_011545176 XP_011543478 XM_011545177 XP_011543479 XM_011545178 XP_011543480 XM_011545179 XP_011543481 XM_011545180 XP_011543482 XR_949996 XR_949997 NM_001300942 NP_001287871 NM_001300943 NP_001287872 NM_001300944 NP_001287873 NM_020193 NP_064578
|
| Function |
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. As part of a histone H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. {ECO:0000269|PubMed:14651845, ECO:0000269|PubMed:19131338}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:14651845}. Note=Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process.
|