| Gene Symbol |
HRASLS2
|
| Entrez Gene |
54979
|
| Alt Symbol |
PLA1/2-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
HRAS-like suppressor 2
|
| Other Description |
-
|
| Swissprots |
B9A7L8 Q9NWW9
|
| Accessions |
EAW74157 Q9NWW9 AB453251 BAH22445 AK000563 BAA91256 BC152862 AAI52863 XM_011545119 XP_011543421 XM_011545120 XP_011543422 NM_017878 NP_060348
|
| Function |
Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC. {ECO:0000269|PubMed:19615464}.
|
| Subcellular Location |
Cytoplasm. Membrane; Single-pass membrane protein. Note=Exhibits a granular pattern in the cytoplasm with preferential perinuclear localization.
|
| Tissue Specificity |
Expressed in liver, kidney, small intestine testis and colon (PubMed:19615464). Undetectable in testis, placenta, salivary gland and fetal brain (PubMed:18163183). {ECO:0000269|PubMed:18163183, ECO:0000269|PubMed:19615464}.
|