Gene Symbol | HRASLS2 |
---|---|
Entrez Gene | 54979 |
Alt Symbol | PLA1/2-2 |
Species | Human |
Gene Type | protein-coding |
Description | HRAS-like suppressor 2 |
Other Description | - |
Swissprots | B9A7L8 Q9NWW9 |
Accessions | EAW74157 Q9NWW9 AB453251 BAH22445 AK000563 BAA91256 BC152862 AAI52863 XM_011545119 XP_011543421 XM_011545120 XP_011543422 NM_017878 NP_060348 |
Function | Exhibits PLA1/2 activity, catalyzing the calcium- independent hydrolysis of acyl groups in various phosphatidylcholines (PC) and phosphatidylethanolamine (PE). For most substrates, PLA1 activity is much higher than PLA2 activity. Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor. Also catalyzes O-acylation converting lyso-PC into PC. {ECO:0000269|PubMed:19615464}. |
Subcellular Location | Cytoplasm. Membrane; Single-pass membrane protein. Note=Exhibits a granular pattern in the cytoplasm with preferential perinuclear localization. |
Tissue Specificity | Expressed in liver, kidney, small intestine testis and colon (PubMed:19615464). Undetectable in testis, placenta, salivary gland and fetal brain (PubMed:18163183). {ECO:0000269|PubMed:18163183, ECO:0000269|PubMed:19615464}. |
HRASLS2 CRISPR/Cas9 KO Plasmid (h) - sc-412404 from Santa Cruz Biotechnology
|
||||||||
HRASLS2 HDR Plasmid (h) - sc-412404-HDR from Santa Cruz Biotechnology
|
||||||||
HRASLS2 Double Nickase Plasmid (h) - sc-412404-NIC from Santa Cruz Biotechnology
|
||||||||
HRASLS2 Double Nickase Plasmid (h2) - sc-412404-NIC-2 from Santa Cruz Biotechnology
|
||||||||
HRASLS2 CRISPR Activation Plasmid (h) - sc-412404-ACT from Santa Cruz Biotechnology
|
||||||||
HRASLS2 CRISPR Activation Plasmid (h2) - sc-412404-ACT-2 from Santa Cruz Biotechnology
|
||||||||
HRASLS2 Lentiviral Activation Particles (h) - sc-412404-LAC from Santa Cruz Biotechnology
|
||||||||
HRASLS2 Lentiviral Activation Particles (h2) - sc-412404-LAC-2 from Santa Cruz Biotechnology
|
||||||||
HRASLS2 siRNA (h) - sc-96654 from Santa Cruz Biotechnology
|
||||||||
HRASLS2 shRNA Plasmid (h) - sc-96654-SH from Santa Cruz Biotechnology
|
||||||||
HRASLS2 shRNA (h) Lentiviral Particles - sc-96654-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU049991 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN10292 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10292 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR00580 from Sigma-Aldrich
|
||||||||
HRASLS2 siRNA (Human) - CRJ0377 from Cohesion Biosciences
|
||||||||
HRASLS2 - MBS8230256 from MyBioSource
|
||||||||
shRNA set against Human HRASLS2 (NM_017878.1) - SHH314797 from Creative biogene
|
||||||||
HRASLS2 shRNA Plasmid (Human) - CHJ0377 from Cohesion Biosciences
|
||||||||
HRASLS2 miRNA 3'UTR clone - MiUTR1H-04692 from Creative biogene
|