RHBDD1

Gene Symbol	RHBDD1
Entrez Gene	84236
Alt Symbol	RRP4
Species	Human
Gene Type	protein-coding
Description	rhomboid domain containing 1
Other Description	rhomboid domain-containing protein 1|rhomboid-like protein 4|rhomboid-related protein 4
Swissprots	Q8IV60 Q53S43 Q8TEB9 Q5EBM8 Q495B9 Q6P5V8 Q9H057
Accessions	AAY24060 EAW70841 EAW70842 Q8TEB9 AK026955 AK074258 BAB85031 AK093986 AL512717 CAC21658 AL832364 AY640233 AAU14246 BC015553 BC027900 AAH27900 BC062636 AAH62636 BC071679 BC089404 AAH89404 BC101262 AAI01263 BC101263 AAI01264 BC101264 AAI01265 BC101265 AAI01266 BC111056 AAI11057 CA434330 DB024396 DQ570409 JF432471 ADZ15688 XM_011511978 XP_011510280 XM_011511979 XP_011510281 XR_923036 XR_923037 XR_923038 XR_923039 XR_923040 NM_001167608 NP_001161080 NM_032276 NP_115652
Function	Intramembrane-cleaving serine protease that cleaves single transmembrane or multi-pass membrane proteins in the hydrophobic plane of the membrane, luminal loops and juxtamembrane regions. Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded membrane proteins. Required for the degradation process of some specific misfolded endoplasmic reticulum (ER) luminal proteins. Participates in the transfer of misfolded proteins from the ER to the cytosol, where they are destroyed by the proteasome in a ubiquitin-dependent manner. Functions in BIK, MPZ, PKD1, PTCRA, RHO, STEAP3 and TRAC processing. Involved in the regulation of exosomal secretion; inhibits the TSAP6-mediated secretion pathway. Involved in the regulation of apoptosis; modulates BIK-mediated apoptotic activity. Also plays a role in the regulation of spermatogenesis; in
Subcellular Location	Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion {ECO:0000305}.
Tissue Specificity	Expressed strongly in testis.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RRP4 protein fragment - ab161632 from Abcam Category Protein Source Wheat germ Species Human

RHBDD1 Antibody Blocking Peptide - LS-E30829 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

RHBDD1 Antibody Blocking Peptide - LS-E22140 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RHBDD1 Blocking Peptide - NBP1-76248PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

RHBDD1-Antibody-C-term-Blocking-Peptide - BP19668b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RHBDD1 Blocking Peptide - 33R-7015 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RHBDD1 Control Peptide - AP30717CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

RHBDD1 Peptide - 5525P from ProSci Category Peptide Species Human

RHBDD1 fusion protein - Ag14932 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RHBDD1 fusion protein - Ag15265 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human RHBDD1, GST-tagged - RHBDD1-2285H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Exosome Component 2 (EXOSC2) - RPH822Hu01 from Cloud-clone Category Protein Source E.coli Species Human

RHBDD1 - TP310708 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RHBDD1 Recombinant Protein Antigen - NBP1-85092PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RHBDD1 Peptide, Human - M34GP13256H from Creative Peptides Category Peptide Source Synthetic. Species Human

Rhomboid domain-containing protein 1 (RHBDD1), Recombinant Protein - MBS7028539 from MyBioSource Category Protein Prices $1,125.00, $2,110.00, $3,320.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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