| Gene Symbol |
PNPLA1
|
| Entrez Gene |
285848
|
| Alt Symbol |
ARCI10, dJ50J22.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
patatin-like phospholipase domain containing 1
|
| Other Description |
patatin-like phospholipase domain-containing protein 1
|
| Swissprots |
Q3SY96 A3RMU3 Q3SY95 Q5R3L2 J3JS20 Q8N8W4 Q2A6N1
|
| Accessions |
EAX03883 Q8N8W4 AK096074 BAC04697 AM182887 CAJ58679 BC103905 AAI03906 BC103906 AAI03907 BC103907 AAI03908 FJ457781 ACJ70710 XM_011514519 XP_011512821 XM_011514520 XP_011512822 XM_011514521 XP_011512823 XM_011514522 XP_011512824 XM_011514523 XP_011512825 XM_011514524 XP_011512826 XM_011514525 XP_011512827 XM_011514526 XP_011512828 NM_001145716 NP_001139188 NM_001145717 NP_001139189 NM_173676 NP_775947 NM_001039725
|
| Function |
Lipid hydrolase. Important in the formation of the epidermal lipid barrier. Plays a role in glycerophospholipid metabolism. {ECO:0000269|PubMed:22246504}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:22246504}. Note=Clearly distributed in the cytoplasm of keratinocytes.
|
| Tissue Specificity |
Expressed in the digestive system. Expressed in the epidermis of skin keratinocytes. Strongly expressed in the granular layer. Expressed in the upper epidermis and eccrine sweat glands of the dermis and in the region of keratin filament bundles, which is more pronounced in upper epidermal layers and in the lower cornified layers. {ECO:0000269|PubMed:16799181, ECO:0000269|PubMed:22246504}.
|