| Gene Symbol |
FOXP2
|
| Entrez Gene |
93986
|
| Alt Symbol |
CAGH44, SPCH1, TNRC10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
forkhead box P2
|
| Other Description |
CAG repeat protein 44|forkhead box protein P2|forkhead/winged-helix transcription factor|trinucleotide repeat containing 10|trinucleotide repeat-containing gene 10 protein
|
| Swissprots |
Q8TD74 Q8NFQ2 Q75MJ3 B4DLD9 A0AUV6 Q8N0W2 Q8NFQ1 Q8NFQ4 Q8N6B7 Q8N6B8 Q8NFQ3 A4D0U8 Q6ZND1 O15409 Q8IZE0 A6NNW4
|
| Accessions |
AAN03389 AAN03390 AAN03391 AAN03392 AAN03393 AAN03394 AAN03395 AAN03396 AAN03397 AAN03398 AAN03399 AAN03400 AAN03401 AAN03402 AAN03403 AAN03404 AAN03405 AAN03406 AAN03407 AAN03408 AAS07399 AAS07400 AAS07502 EAL24367 EAL24368 EAL24369 EAW83479 EAW83480 EAW83481 EAW83482 EAW83483 EAW83484 EAW83485 EAW83486 O15409 AF086040 AF337817 AAL10762 AF454830 AAM60761 AF467252 AAM60762 AF467253 AAM60763 AF467254 AAM60764 AF467255 AAM60765 AF467256 AAM60766 AF467257 AAM60767 AF467258 AAM60768 AF467259 AAM60769 AF493430 AAM13672 AI369947 AK131266 BAD18444 AK296957 BAG59501 AY144615 AAN60016 BC018016 BC126104 AAI26105 BC143866 AAI43867 BC143867 AAI43868 CR749236 CAH18092 DA400243 DQ778626 ABG77460 HQ258624 ADR83376 KJ534839 AHW56479 KJ535079 AHW56718 KJ535086 AHW56725 XM_011516706 XP_011515008 NM_001172766 NP_001166237 NM_001172767 NP_001166238 NM_014491 NP_055306 NM_148898 NP_683696 NM_148899 NP_683697 NM_148900 NP_683698 NR_033766 NR_033767
|
| Function |
Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Plays a role in synapse formation by regulating SRPX2 levels. Involved in neural mechanisms mediating the development of speech and language.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Isoform 1 and isoform 6 are expressed in adult and fetal brain, caudate nucleus and lung. {ECO:0000269|PubMed:12189486}.
|
![Western Blot: FOXP2 Overexpression Lysate (Adult Normal) [NBP2-05428] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FOXP2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5433_FOXP2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-05428-img0001.jpg)