Gene Symbol | SMARCB1 |
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Entrez Gene | 6598 |
Alt Symbol | BAF47, INI1, MRD15, PPP1R144, RDT, RTPS1, SNF5, SNF5L1, SWNTS1, Sfh1p, Snr1, hSNFS |
Species | Human |
Gene Type | protein-coding |
Description | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 |
Other Description | BRG1-associated factor 47|SNF5 homolog|SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1|SWI/SNF-related matrix-associated protein|hSNF5|integrase interactor 1 protein|malignant rhabdoid tumor suppressor|protein phosphatase 1, regulatory subunit 144|sucrose nonfermenting, yeast, homolog-like 1 |
Swissprots | O95474 Q76N08 Q38GA1 Q17S11 O75784 Q9UBH2 Q12824 |
Accessions | AAB34227 ABB02184 CAA76639 EAW59605 EAW59606 EAW59607 EAW59608 Q12824 AB017523 BAC77068 AJ011737 CAA09758 AJ011738 CAA09759 AK021419 BAG51033 AK024025 BAB14784 AK299411 BAG61393 AK303620 BAG64629 AL389878 AL389881 AU143041 AY207470 AAO59166 AY207471 AAO59167 AY207472 AAO59168 AY562997 AAS75587 BC117114 AAI17115 BC143667 AAI43668 BG705851 CR456581 CAG30467 CU013180 CAK54611 CU013468 CAK54910 HQ258224 ADR82978 R37717 XM_011530345 XP_011528647 XM_011530346 XP_011528648 XM_011546908 XP_011545210 XM_011546909 XP_011545211 NM_001007468 NP_001007469 NM_003073 NP_003064 |
Function | Core component of the BAF (hSWI/SNF) complex. This ATP- dependent chromatin-remodeling complex plays important roles in cell proliferation and differentiation, in cellular antiviral activities and inhibition of tumor formation. The BAF complex is able to create a stable, altered form of chromatin that constrains fewer negative supercoils than normal. This change in supercoiling would be due to the conversion of up to one-half of the nucleosomes on polynucleosomal arrays into asymmetric structures, termed altosomes, each composed of 2 histones octamers. Stimulates in vitro the remodeling activity of SMARCA4/BRG1/BAF190A. Involved in activation of CSF1 promoter. Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to thei |
Subcellular Location | Nucleus. |
Ini1 CRISPR/Cas9 KO Plasmid (h) - sc-401485 from Santa Cruz Biotechnology
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Ini1 HDR Plasmid (h) - sc-401485-HDR from Santa Cruz Biotechnology
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Ini1 Double Nickase Plasmid (h) - sc-401485-NIC from Santa Cruz Biotechnology
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Ini1 Double Nickase Plasmid (h2) - sc-401485-NIC-2 from Santa Cruz Biotechnology
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Ini1 CRISPR Activation Plasmid (h) - sc-401485-ACT from Santa Cruz Biotechnology
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Ini1 CRISPR Activation Plasmid (h2) - sc-401485-ACT-2 from Santa Cruz Biotechnology
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Ini1 Lentiviral Activation Particles (h) - sc-401485-LAC from Santa Cruz Biotechnology
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Ini1 Lentiviral Activation Particles (h2) - sc-401485-LAC-2 from Santa Cruz Biotechnology
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Ini1 siRNA (h) - sc-35668 from Santa Cruz Biotechnology
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Ini1 shRNA Plasmid (h) - sc-35668-SH from Santa Cruz Biotechnology
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Ini1 shRNA (h) Lentiviral Particles - sc-35668-V from Santa Cruz Biotechnology
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SNF5 RNAi - H00006598-R02 from Novus Biologicals
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MISSION® esiRNA - EHU100321 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1550 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1549 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1550 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1549 from Sigma-Aldrich
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SMARCB1 siRNA (Human) - CRH4482 from Cohesion Biosciences
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SNF5 RNAi - H00006598-R01 from Novus Biologicals
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SMARCB1 - MBS8204099 from MyBioSource
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shRNA set against Human SMARCB1 (NM_003073.3) - SHH413148 from Creative biogene
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shRNA set against Human SMARCB1(NM_003073.3) - SHL015830 from Creative biogene
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shRNA set against Human SMARCB1(NM_001007468.1) - SHL015894 from Creative biogene
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shRNA set against Human SMARCB1(NM_003073.3) - SHL015948 from Creative biogene
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Human SMARCB1 siRNA - orb264984 from Biorbyt
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