| Gene Symbol |
GPR84
|
| Entrez Gene |
53831
|
| Alt Symbol |
EX33, GPCR4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor 84
|
| Other Description |
G-protein coupled receptor 84|inflammation-related G protein-coupled receptor EX33|inflammation-related G-protein coupled receptor EX33
|
| Swissprots |
B6V9G7 Q9NQS5
|
| Accessions |
BAB89299 EAW96776 Q9NQS5 AF237762 AAK01857 AF282693 AAF91467 AK290394 BAF83083 BC020614 AAH20614 BP303386 CD366881 DQ893217 ABM84143 DQ896546 ABM87545 FJ348261 ACI96305 XM_011538495 XP_011536797 XM_011538496 XP_011536798 NM_020370 NP_065103
|
| Function |
Receptor for medium-chain free fatty acid (FFA) with carbon chain lengths of C9 to C14. Capric acid (C10:0), undecanoic acid (C11:0) and lauric acid (C12:0) are the most potent agonists. Not activated by short-chain and long-chain saturated and unsaturated FFAs. Activation by medium-chain free fatty acid is coupled to a pertussis toxin sensitive G(i/o) protein pathway. May have important roles in processes from fatty acid metabolism to regulation of the immune system. {ECO:0000269|PubMed:16966319}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed predominantly in hematopoietic tissues. High levels detected in the bone marrow and lower levels in the peripheral leukocytes and lung. Also expressed in brain, heart, muscle, colon, thymus, spleen, kidney, liver, placenta and intestine. Within the leukocyte population expression is higher in neutrophils and eosinophils relative to T- or B-lymphocytes. {ECO:0000269|PubMed:11273702, ECO:0000269|PubMed:11404393, ECO:0000269|PubMed:16966319}.
|