| Gene Symbol | POLR2L |
|---|---|
| Entrez Gene | 5441 |
| Alt Symbol | RBP10, RPABC5, RPB10, RPB10beta, RPB7.6, hRPB7.6 |
| Species | Human |
| Gene Type | protein-coding |
| Description | polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa |
| Other Description | DNA-directed RNA polymerase III subunit L|DNA-directed RNA polymerases I, II, and III subunit RPABC5|RNA polymerase II 7.6 kDa subunit|RNA polymerases I, II, and III subunit ABC5|RPB10 homolog |
| Swissprots | P62875 Q6FHX3 |
| Accessions | CAA87657 CAA87658 EAX02408 P62875 AJ420546 AK311997 BAG34935 BC005903 AAH05903 BC018649 AAH18649 BQ435190 BU679804 CR536565 CAG38802 DQ893146 ABM84072 DQ896440 ABM87439 DQ896562 ABM87561 U37690 AAA91459 NM_021128 NP_066951 |
| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:16809778, ECO:0000269|PubMed:9852112}. |
| Top Pathways | Huntington's disease, Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase |