POLR2L

Gene Symbol POLR2L
Entrez Gene 5441
Alt Symbol RBP10, RPABC5, RPB10, RPB10beta, RPB7.6, hRPB7.6
Species Human
Gene Type protein-coding
Description polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa
Other Description DNA-directed RNA polymerase III subunit L|DNA-directed RNA polymerases I, II, and III subunit RPABC5|RNA polymerase II 7.6 kDa subunit|RNA polymerases I, II, and III subunit ABC5|RPB10 homolog
Swissprots P62875 Q6FHX3
Accessions CAA87657 CAA87658 EAX02408 P62875 AJ420546 AK311997 BAG34935 BC005903 AAH05903 BC018649 AAH18649 BQ435190 BU679804 CR536565 CAG38802 DQ893146 ABM84072 DQ896440 ABM87439 DQ896562 ABM87561 U37690 AAA91459 NM_021128 NP_066951
Function DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2L/RBP10 is part of the core element with the central large cleft (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:16809778, ECO:0000269|PubMed:9852112}.
Top Pathways Huntington's disease, Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase

POLR2L CRISPR/Cas9 KO Plasmid (h) - sc-410949 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR2L HDR Plasmid (h) - sc-410949-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR2L Double Nickase Plasmid (h) - sc-410949-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR2L Double Nickase Plasmid (h2) - sc-410949-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR2L CRISPR Activation Plasmid (h) - sc-410949-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR2L CRISPR Activation Plasmid (h2) - sc-410949-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR2L Lentiviral Activation Particles (h) - sc-410949-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR2L Lentiviral Activation Particles (h2) - sc-410949-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

POLR2L siRNA (h) - sc-96685 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

POLR2L shRNA Plasmid (h) - sc-96685-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

POLR2L shRNA (h) Lentiviral Particles - sc-96685-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU003511 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17125 from Sigma-Aldrich

Category ZFN Kit

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17125 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05393 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05393

POLR2L siRNA (Human) - CRH3644 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human POLR2L siRNA - orb264146 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

POLR2L shRNA Plasmid (Human) - CHH3644 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

POLR2L miRNA 3'UTR clone - MiUTR3H-03935 from Creative biogene

Species Reactivities Human
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