CREM
| Gene Symbol | CREM |
|---|---|
| Entrez Gene | 1390 |
| Alt Symbol | CREM-2, ICER, hCREM-2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | cAMP responsive element modulator |
| Other Description | CREM 2alpha-b protein|CREM 2beta-a protein|cAMP response element modulator|cAMP-responsive element modulator|inducible cAMP early repressor ICER |
| Swissprots | Q5W1A6 Q14501 Q16116 Q7Z2Q6 Q5T9H7 Q9NZB9 A8K3J7 C9JZ10 Q8IVD4 A8MPQ2 E9PAR4 Q14506 Q5W1A7 Q5W1A8 O75519 Q9NZ98 Q96AG7 Q14504 C9J785 B4DXC1 A8K6A1 Q16114 Q5W1B0 Q03060 A8K014 Q15731 E9PHM1 Q9NZ99 Q14505 Q5W1B2 Q5W1A9 Q14503 |
| Accessions | AAF66158 AAF68266 AAF68682 AAG47575 EAW85916 EAW85917 EAW85918 EAW85919 EAW85920 Q03060 AA453346 AB209533 BAD92770 AF069065 AAC19383 AF417233 AAN32655 AF417234 AAN32656 AK289379 BAF82068 AK290612 BAF83301 AK291566 BAF84255 AK301906 BAG63333 AU140010 AV707433 AW439476 AY292864 AAP44115 BC017117 AAH17117 BC041810 BC066342 AAH66342 BC090051 AAH90051 BE439480 BG573680 BG719264 BG720999 BI459432 BI561543 BP370901 BU193626 BU570307 BX379412 CB996061 CD358637 CD639591 CD640465 CD640977 CD686814 CK300763 CN367927 D14825 BAA03562 D14826 BAA03564 DA756152 DR760671 DT220562 HG502806 S68134 AAC60617 S68271 AAC60616 U44836 AAB03751 Y08959 Z15159 CAA78858 XM_006717378 XP_006717441 XM_006717379 XP_006717442 XM_006717382 XP_006717445 XM_006717383 XP_006717446 XM_006717387 XP_006717450 XM_011519316 XP_011517618 XM_011519317 XP_011517619 XM_011519318 XP_011517620 XM_011519319 XP_011517621 XM_011519320 XP_011517622 XM_011519321 XP_011517623 XM_011519322 XP_011517624 XM_011519323 XP_011517625 XM_011519324 XP_011517626 XM_011519325 XP_011517627 XM_011519326 XP_011517628 XM_011519327 XP_011517629 XM_011519328 XP_011517630 XM_011519329 XP_011517631 XM_011519330 XP_011517632 XM_011519331 XP_011517633 XM_011519332 XP_011517634 XM_011519333 XP_011517635 XM_011519334 XP_011517636 XM_011519335 XP_011517637 XM_011519336 XP_011517638 NM_001267562 NP_001254491 NM_001267563 NP_001254492 NM_001267564 NP_001254493 NM_001267565 NP_001254494 NM_001267566 NP_001254495 NM_001267567 NP_001254496 NM_001267568 NP_001254497 NM_001267569 NP_001254498 NM_001267570 NP_001254499 NM_001881 NP_001872 NM_181571 NP_853549 NM_182717 NP_874386 NM_182718 NP_874387 NM_182719 NP_874388 NM_182720 NP_874389 NM_182721 NP_874390 NM_182723 NP_874392 NM_182724 NP_874393 NM_182769 NP_877570 NM_182770 NP_877571 NM_182771 NP_877572 NM_182772 NP_877573 NM_183011 NP_898829 NM_183012 NP_898830 NM_183013 NP_898831 NM_183060 NP_898883 NR_051971 NR_051972 NR_051973 NR_051974 NR_051975 NM_182722 NM_182725 NM_182850 NM_182853 |
| Function | Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). {ECO:0000269|PubMed:10373550}. |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. {ECO:0000269|PubMed:11044457, ECO:0000269|PubMed:14511788, ECO:0000269|PubMed:16143638}. |
| Top Pathways | HTLV-I infection, Adrenergic signaling in cardiomyocytes |
CREM CRISPR/Cas9 KO Plasmid (h) - sc-400406 from Santa Cruz Biotechnology
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CREM HDR Plasmid (h) - sc-400406-HDR from Santa Cruz Biotechnology
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CREM Double Nickase Plasmid (h) - sc-400406-NIC from Santa Cruz Biotechnology
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CREM Double Nickase Plasmid (h2) - sc-400406-NIC-2 from Santa Cruz Biotechnology
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CREM CRISPR Activation Plasmid (h) - sc-400406-ACT from Santa Cruz Biotechnology
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CREM CRISPR Activation Plasmid (h2) - sc-400406-ACT-2 from Santa Cruz Biotechnology
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CREM Lentiviral Activation Particles (h) - sc-400406-LAC from Santa Cruz Biotechnology
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CREM Lentiviral Activation Particles (h2) - sc-400406-LAC-2 from Santa Cruz Biotechnology
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CREM siRNA (h) - sc-37700 from Santa Cruz Biotechnology
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CREM shRNA Plasmid (h) - sc-37700-SH from Santa Cruz Biotechnology
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CREM shRNA (h) Lentiviral Particles - sc-37700-V from Santa Cruz Biotechnology
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CREM RNAi - H00001390-R01 from Novus Biologicals
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CREM RNAi - H00001390-R10 from Novus Biologicals
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CREM RNAi - H00001390-R06 from Novus Biologicals
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CREM RNAi - H00001390-R11 from Novus Biologicals
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CREM RNAi - H00001390-R02 from Novus Biologicals
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CREM RNAi - H00001390-R16 from Novus Biologicals
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CREM RNAi - H00001390-R09 from Novus Biologicals
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CREM RNAi - H00001390-R13 from Novus Biologicals
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CREM RNAi - H00001390-R17 from Novus Biologicals
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CREM RNAi - H00001390-R08 from Novus Biologicals
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CREM RNAi - H00001390-R04 from Novus Biologicals
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CREM RNAi - H00001390-R21 from Novus Biologicals
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MISSION® esiRNA - EHU125161 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6565 from Sigma-Aldrich
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