CREM

Gene Symbol CREM
Entrez Gene 1390
Alt Symbol CREM-2, ICER, hCREM-2
Species Human
Gene Type protein-coding
Description cAMP responsive element modulator
Other Description CREM 2alpha-b protein|CREM 2beta-a protein|cAMP response element modulator|cAMP-responsive element modulator|inducible cAMP early repressor ICER
Swissprots Q5W1A6 Q14501 Q16116 Q7Z2Q6 Q5T9H7 Q9NZB9 A8K3J7 C9JZ10 Q8IVD4 A8MPQ2 E9PAR4 Q14506 Q5W1A7 Q5W1A8 O75519 Q9NZ98 Q96AG7 Q14504 C9J785 B4DXC1 A8K6A1 Q16114 Q5W1B0 Q03060 A8K014 Q15731 E9PHM1 Q9NZ99 Q14505 Q5W1B2 Q5W1A9 Q14503
Accessions AAF66158 AAF68266 AAF68682 AAG47575 EAW85916 EAW85917 EAW85918 EAW85919 EAW85920 Q03060 AA453346 AB209533 BAD92770 AF069065 AAC19383 AF417233 AAN32655 AF417234 AAN32656 AK289379 BAF82068 AK290612 BAF83301 AK291566 BAF84255 AK301906 BAG63333 AU140010 AV707433 AW439476 AY292864 AAP44115 BC017117 AAH17117 BC041810 BC066342 AAH66342 BC090051 AAH90051 BE439480 BG573680 BG719264 BG720999 BI459432 BI561543 BP370901 BU193626 BU570307 BX379412 CB996061 CD358637 CD639591 CD640465 CD640977 CD686814 CK300763 CN367927 D14825 BAA03562 D14826 BAA03564 DA756152 DR760671 DT220562 HG502806 S68134 AAC60617 S68271 AAC60616 U44836 AAB03751 Y08959 Z15159 CAA78858 XM_006717378 XP_006717441 XM_006717379 XP_006717442 XM_006717382 XP_006717445 XM_006717383 XP_006717446 XM_006717387 XP_006717450 XM_011519316 XP_011517618 XM_011519317 XP_011517619 XM_011519318 XP_011517620 XM_011519319 XP_011517621 XM_011519320 XP_011517622 XM_011519321 XP_011517623 XM_011519322 XP_011517624 XM_011519323 XP_011517625 XM_011519324 XP_011517626 XM_011519325 XP_011517627 XM_011519326 XP_011517628 XM_011519327 XP_011517629 XM_011519328 XP_011517630 XM_011519329 XP_011517631 XM_011519330 XP_011517632 XM_011519331 XP_011517633 XM_011519332 XP_011517634 XM_011519333 XP_011517635 XM_011519334 XP_011517636 XM_011519335 XP_011517637 XM_011519336 XP_011517638 NM_001267562 NP_001254491 NM_001267563 NP_001254492 NM_001267564 NP_001254493 NM_001267565 NP_001254494 NM_001267566 NP_001254495 NM_001267567 NP_001254496 NM_001267568 NP_001254497 NM_001267569 NP_001254498 NM_001267570 NP_001254499 NM_001881 NP_001872 NM_181571 NP_853549 NM_182717 NP_874386 NM_182718 NP_874387 NM_182719 NP_874388 NM_182720 NP_874389 NM_182721 NP_874390 NM_182723 NP_874392 NM_182724 NP_874393 NM_182769 NP_877570 NM_182770 NP_877571 NM_182771 NP_877572 NM_182772 NP_877573 NM_183011 NP_898829 NM_183012 NP_898830 NM_183013 NP_898831 NM_183060 NP_898883 NR_051971 NR_051972 NR_051973 NR_051974 NR_051975 NM_182722 NM_182725 NM_182850 NM_182853
Function Transcriptional regulator that binds the cAMP response element (CRE), a sequence present in many viral and cellular promoters. Isoforms are either transcriptional activators or repressors. Plays a role in spermatogenesis and is involved in spermatid maturation (PubMed:10373550). {ECO:0000269|PubMed:10373550}.
Subcellular Location Nucleus.
Tissue Specificity Expressed in testes (round spermatids) (at protein level). Isoform 14 is the major activator form in testes. {ECO:0000269|PubMed:11044457, ECO:0000269|PubMed:14511788, ECO:0000269|PubMed:16143638}.
Top Pathways HTLV-I infection, Adrenergic signaling in cardiomyocytes

CREM (X-12) - sc-440 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
CREM (X-12): sc-440. Western blot analysis of ATF-1/CREB gene family product expression in Jurkat (A) and KNRK (B) nuclear extracts and recombinant mouse His-tagged CREM (FL): sc-4005 (C) and an unrelated His-tagged protein (D).

CREM (22) - sc-101530 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
CREM (22): sc-101530. Western blot analysis of human recombinant CREM.

CREM (Y-12) - sc-34026 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

CREM (C-12) - sc-34024 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
CREM (C-12): sc-34024. Western blot analysis of CREM expression in rat heart tissue extract.

CREM (S-12) - sc-34028 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-CREM antibody - ab64832 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-CREM antibody (ab64832) at 1/500 dilutionLane 1 : K562 cell extractLane 2 : K562 cell extract with immunising peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-CREM antibody - ab54625 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab54625 CREM antibody at 1ug/ml.

Anti-CREM antibody - ab23940 from Abcam

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-CREM antibody (ab23940) at 1 µg/mlPerformed under reducing conditions.

Anti-CREM / ICER Antibody (Ile106) - LS-C191971 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CREM / ICER Antibody - LS-C309991 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CREM / ICER Antibody - LS-C137535 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CREM / ICER Antibody - LS-C341141 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CREM / ICER Antibody (aa19-68) - LS-C30561 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
A: Marker, B: Jurkat Cell Lysate

Anti-CREM / ICER Antibody (C-Terminus) - LS-C151194 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
CREM / ICER antibody Western Blot of Rat Thymus.

Anti-CREM / ICER Antibody (C-Terminus) - LS-C54681 from LifeSpan Bioscience

Host Goat
Clonality Polyclonal
Antibody staining (1 ug/ml) of human heart lysate (RIPA buffer, 35 ug total protein per lane). Primary incubated for 1 hour. Detected by Western blot of chemiluminescence.

Anti-CREM / ICER Antibody (C-Terminus) - LS-C345659 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-CREM / ICER Antibody (aa81-130) - LS-C118982 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of extracts from RAW264.7 cells, using CREM Antibody. The lane on the right is treated with the synthesized peptide.

Anti-CREM / ICER Antibody (Internal) - LS-C345513 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of CREM Antibody with human Fetal Kidney lysate.

Anti-CREM / ICER Antibody (clone 3B5) - LS-C196963 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal
Clone 3B5
Immunofluorescence of monoclonal antibody to CREM on HeLa cell . [antibody concentration 10 ug/ml]

Anti-CREM / ICER Antibody - LS-C335590 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using CREM antibody.

Anti-CREM / ICER Antibody (aa277-307) - LS-C167033 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal
Western blot of CREM Antibody in HeLa cell line lysates (35 ug/lane). CREM (arrow) was detected using the purified antibody.

CREM Antibody - NBP1-81760 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CREM Antibody [NBP1-81760] - Western blot analysis in mouse cell line NIH-3T3, rat cell line NBT-II and rat cell line pC12.

CREM Antibody - NBP2-16009 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: CREM Antibody [NBP2-16009] - Sample (30 ug of whole cell lysate) A: NT2D1 12% SDS PAGE gel, diluted at 1:1000.

CREM [p Ser271, p Ser274] Antibody - NBP1-03435 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Sheep
Clonality Polyclonal

CREM [p Ser271, p Ser274] Antibody - NBP1-03391 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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